Literature DB >> 17013380

Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity.

P M Fisher1, C C Meltzer, S K Ziolko, J C Price, E L Moses-Kolko, S L Berga, A R Hariri.   

Abstract

We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30-44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.

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Year:  2006        PMID： 17013380     DOI： 10.1038/nn1780

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  61 in total

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