Literature DB >> 17012783

Structure of armadillo ACBP: a new member of the acyl-CoA-binding protein family.

Marcelo D Costabel1, Mario R Ermácora, José A Santomé, Pedro M Alzari, Diego M A Guérin.   

Abstract

The X-ray structure of the tetragonal form of apo acyl-CoA-binding protein (ACBP) from the Harderian gland of the South American armadillo Chaetophractus villosus has been solved. ACBP is a carrier for activated long-chain fatty acids and has been associated with many aspects of lipid metabolism. Its secondary structure is highly similar to that of the corresponding form of bovine ACBP and exhibits the unique flattened alpha-helical bundle (up-down-down-up) motif reported for animal, yeast and insect ACBPs. Conformational differences are located in loops and turns, although these structural differences do not suffice to account for features that could be related to the unusual biochemistry and lipid metabolism of the Harderian gland.

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Year:  2006        PMID： 17012783      PMCID： PMC2225200          DOI： 10.1107/S1744309106038164

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


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