BACKGROUND: The authors compared the in vivo antimicrobial effects on microorganisms from dental plaque, saliva and the tongue in subjects who used a triclosan/copolymer dentifrice and a fluoride dentifrice (control). METHODS: The authors assigned 15 subjects randomly to the control dentifrice or the triclosan/copolymer dentifrice for twice-daily use for one week. They collected samples of plaque, saliva and tongue scrapings six and 12 hours after the final brushing. They analyzed colony-forming units of Veillonella species, Fusobacteria species, total cultivable anaerobes and hydrogen sulfide (H(2)S)-producing bacteria. A one-week washout followed. The authors repeated the protocol with the second dentifrice. RESULTS: The results showed no differences at baseline. Significant reductions (88 to 96 percent) in oral anaerobic bacteria were observed in the triclosan/copolymer group six and 12 hours after brushing compared with the control group (P = .001). Fusobacteria decreased by 77 to 92 percent and Veillonella decreased by 84 to 89 percent six and 12 hours after brushing in the triclosan/copolymer group versus the control group. The triclosan/copolymer group also demonstrated a significant decrease in H(2)S-producing bacteria six and 12 hours after brushing (74 to 85 percent) (P = .001). CONCLUSIONS: Brushing with the triclosan/copolymer dentifrice resulted in significant reductions in microorganisms from the three sites compared with the control dentifrice. CLINICAL IMPLICATIONS: The triclosan/copolymer dentifrice produced sustained effects on oral bacteria for 12 hours.
RCT Entities:
BACKGROUND: The authors compared the in vivo antimicrobial effects on microorganisms from dental plaque, saliva and the tongue in subjects who used a triclosan/copolymer dentifrice and a fluoride dentifrice (control). METHODS: The authors assigned 15 subjects randomly to the control dentifrice or the triclosan/copolymer dentifrice for twice-daily use for one week. They collected samples of plaque, saliva and tongue scrapings six and 12 hours after the final brushing. They analyzed colony-forming units of Veillonella species, Fusobacteria species, total cultivable anaerobes and hydrogen sulfide (H(2)S)-producing bacteria. A one-week washout followed. The authors repeated the protocol with the second dentifrice. RESULTS: The results showed no differences at baseline. Significant reductions (88 to 96 percent) in oral anaerobic bacteria were observed in the triclosan/copolymer group six and 12 hours after brushing compared with the control group (P = .001). Fusobacteria decreased by 77 to 92 percent and Veillonella decreased by 84 to 89 percent six and 12 hours after brushing in the triclosan/copolymer group versus the control group. The triclosan/copolymer group also demonstrated a significant decrease in H(2)S-producing bacteria six and 12 hours after brushing (74 to 85 percent) (P = .001). CONCLUSIONS: Brushing with the triclosan/copolymer dentifrice resulted in significant reductions in microorganisms from the three sites compared with the control dentifrice. CLINICAL IMPLICATIONS: The triclosan/copolymer dentifrice produced sustained effects on oral bacteria for 12 hours.
Authors: Marieke P T Otten; Henk J Busscher; Frank Abbas; Henny C van der Mei; Chris G van Hoogmoed Journal: Clin Oral Investig Date: 2011-12-13 Impact factor: 3.573
Authors: P K Sreenivasan; D Furgang; K Markowitz; M McKiernan; D Tischio-Bereski; W Devizio; D Fine Journal: Clin Oral Investig Date: 2008-10-11 Impact factor: 3.573
Authors: Tadeusz Morawiec; Anna Mertas; Robert D Wojtyczka; Iwona Niedzielska; Arkadiusz Dziedzic; Anna Bubiłek-Bogacz; Jakub Sender; Jacek Wróbel; Marta Tanasiewicz; Piotr Wesołowski; Wojciech Król Journal: Biomed Res Int Date: 2015-08-26 Impact factor: 3.411