| Literature DB >> 17011779 |
Sirisilla Raju1, P Rajender Kumar, K Mukkanti, Pazhanimuthu Annamalai, Manojit Pal.
Abstract
The first successful Pd/C-mediated Sonogashira coupling of iodothiophene with terminal alkynes in water is described here. Pd/C-CuI-PPh(3) was found to be an efficient catalyst system for this coupling reaction. Using this economic and reliable process a variety of acetylenic thiophenes with a wide range of functional groups were prepared in good yields. Synthetic applications and in vitro anticancer properties of some of the compounds synthesized are described.Entities:
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Year: 2006 PMID： 17011779 DOI： 10.1016/j.bmcl.2006.09.041
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823