| Literature DB >> 17011235 |
Taisuke Horimoto1, Yoshihiro Kawaoka.
Abstract
Recent outbreaks of highly pathogenic avian influenza A virus (H5N1 subtype) infections in poultry and humans (through direct contact with infected birds) have raised concerns that a new influenza pandemic might occur in the near future. Effective vaccines against H5N1 virus are, therefore, urgently needed. Reverse-genetics-based inactivated vaccines have been prepared according to World Health Organization (WHO) recommendations and are now undergoing clinical evaluation in several countries. Here, we review the current strategies for the development of H5N1 influenza vaccines, and future directions for vaccine development.Entities:
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Year: 2006 PMID： 17011235 DOI： 10.1016/j.molmed.2006.09.003
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951