Literature DB >> 17010937

Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation.

Daisuke Nanba1, Yumi Kinugasa, Chie Morimoto, Michiko Koizumi, Hisako Yamamura, Katsuhito Takahashi, Nobuyuki Takakura, Eisuke Mekada, Koji Hashimoto, Shigeki Higashiyama.   

Abstract

Epidermal growth factor (EGF) and ErbB family molecules play a role in heart development and function. To investigate the role of EGF family member, heparin-binding EGF-like growth factor (HB-EGF) in heart development, smooth muscle and endothelial cell lineage-specific HB-EGF knockout mice were generated using the Cre/loxP system in combination with the SM22alpha or TIE2 promoter. HB-EGF knockout mice displayed enlarged heart valves, and over half of these mice died during the first postnatal week, while survivors showed cardiac hypertrophy. These results suggest that expression of HB-EGF in smooth muscle and/or endothelial cell lineages is essential for proper heart development and function in mice.

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Year:  2006        PMID： 17010937     DOI： 10.1016/j.bbrc.2006.09.060

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines.

Authors:  Jessica Lauriol; Janel R Cabrera; Ashbeel Roy; Kimberly Keith; Sara M Hough; Federico Damilano; Bonnie Wang; Gabriel C Segarra; Meaghan E Flessa; Lauren E Miller; Saumya Das; Roderick Bronson; Kyu-Ho Lee; Maria I Kontaridis
Journal:  J Clin Invest       Date:  2016-06-27       Impact factor: 14.808

2.  Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7.

Authors:  Frederic Sierro; Christine Biben; Laura Martínez-Muñoz; Mario Mellado; Richard M Ransohoff; Meizhang Li; Blanche Woehl; Helen Leung; Joanna Groom; Marcel Batten; Richard P Harvey; Carlos Martínez-A; Charles R Mackay; Fabienne Mackay
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-05       Impact factor: 11.205

3.  Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults.

Authors:  Carole L Wilson; Peter J Gough; Cindy A Chang; Christina K Chan; Jeremy M Frey; Yonggang Liu; Kathleen R Braun; Michael T Chin; Thomas N Wight; Elaine W Raines
Journal:  Mech Dev       Date:  2013-01-24       Impact factor: 1.882

4.  Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development.

Authors:  Seonwook Kim; Lihua Yang; Seongu Kim; Richard G Lee; Mark J Graham; Judith A Berliner; Aldons J Lusis; Lei Cai; Ryan E Temel; Debra L Rateri; Sangderk Lee
Journal:  PLoS One       Date:  2017-08-09       Impact factor: 3.240

5.  Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2-Mediated Paracrine Signaling.

Authors:  Riikka Kivelä; Karthik Amudhala Hemanthakumar; Katri Vaparanta; Marius Robciuc; Yasuhiro Izumiya; Hiroyasu Kidoya; Nobuyuki Takakura; Xuyang Peng; Douglas B Sawyer; Klaus Elenius; Kenneth Walsh; Kari Alitalo
Journal:  Circulation       Date:  2019-03-29       Impact factor: 29.690

6.  Specific endothelial heparin-binding EGF-like growth factor deletion ameliorates renal injury induced by chronic angiotensin II infusion.

Authors:  Fenghua Zeng; Lance A Kloepfer; Charlene Finney; André Diedrich; Raymond C Harris
Journal:  Am J Physiol Renal Physiol       Date:  2016-05-25

Review 7.  Angiogenesis and angiocrines regulating heart growth.

Authors:  Karthik Amudhala Hemanthakumar; Riikka Kivelä
Journal:  Vasc Biol       Date:  2020-06-22
  7 in total

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