| Literature DB >> 17010628 |
Yun-Sang Lee1, Jae Min Jeong, Young Joo Kim, Young Soo Chang, Hak Jeong Lee, Miwon Son, Jung Woo Lee, Heung Sik Yoon, Won Jun Kang, Dong Soo Lee, June-Key Chung, Myung Chul Lee, Young-Ger Suh.
Abstract
A lipiodol solution of (188)Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol ((188)Re-HDD/lipiodol) is in clinical study for liver cancer therapy. However, formulation of it is difficult due to highly active and unstable sulfhydryl groups. We produced new kits using diacetylated HDD (AHDD), in which sulfhydryl groups are protected. We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice.Entities:
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Year: 2006 PMID： 17010628 DOI： 10.1016/j.apradiso.2006.07.008
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513