Literature DB >> 1701023

Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells.

B R Stanton1, S W Reid, L F Parada.   

Abstract

We have disrupted one allele of the N-myc locus in mouse embryonic stem (ES) cells by using homologous recombination techniques and have obtained germ line transmission of null N-myc ES cell lines with transmission of the null N-myc allele to the offspring. The creation of mice with a deficient N-myc allele will allow the generation of offspring bearing null N-myc alleles in both chromosomes and permit study of the role that this proto-oncogene plays in embryonic development.

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Year:  1990        PMID： 1701023      PMCID： PMC362953          DOI： 10.1128/mcb.10.12.6755-6758.1990

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  15 in total

Review 1.  Altering the genome by homologous recombination.

Authors:  M R Capecchi
Journal:  Science       Date:  1989-06-16       Impact factor: 47.728

2.  Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo.

Authors:  K M Downs; G R Martin; J M Bishop
Journal:  Genes Dev       Date:  1989-06       Impact factor: 11.361

Review 3.  Towards a molecular-genetic analysis of mammalian development.

Authors:  J Rossant; A L Joyner
Journal:  Trends Genet       Date:  1989-08       Impact factor: 11.639

4.  Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.

Authors:  K R Thomas; M R Capecchi
Journal:  Cell       Date:  1987-11-06       Impact factor: 41.582

5.  Structure and expression of the murine N-myc gene.

Authors:  R A DePinho; E Legouy; L B Feldman; N E Kohl; G D Yancopoulos; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

6.  Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.

Authors:  P L Schwartzberg; S P Goff; E J Robertson
Journal:  Science       Date:  1989-11-10       Impact factor: 47.728

7.  Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.

Authors:  M Schwab; K Alitalo; K H Klempnauer; H E Varmus; J M Bishop; F Gilbert; G Brodeur; M Goldstein; J Trent
Journal:  Nature       Date:  1983 Sep 15-21       Impact factor: 49.962

8.  Activated expression of the N-myc gene in human neuroblastomas and related tumors.

Authors:  N E Kohl; C E Gee; F W Alt
Journal:  Science       Date:  1984-12-14       Impact factor: 47.728

9.  Differential expression of myc family genes during murine development.

Authors:  K A Zimmerman; G D Yancopoulos; R G Collum; R K Smith; N E Kohl; K A Denis; M M Nau; O N Witte; D Toran-Allerand; C E Gee
Journal:  Nature       Date:  1986 Feb 27-Mar 5       Impact factor: 49.962

10.  N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization.

Authors:  G Mugrauer; F W Alt; P Ekblom
Journal:  J Cell Biol       Date:  1988-10       Impact factor: 10.539
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  10 in total

1.  Correction of a human beta S-globin gene by gene targeting.

Authors:  E G Shesely; H S Kim; W R Shehee; T Papayannopoulou; O Smithies; B W Popovich
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

2.  Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes.

Authors:  Roland H Friedel; Andrew Plump; Xiaowei Lu; Kerri Spilker; Christine Jolicoeur; Karen Wong; Tadmiri R Venkatesh; Avraham Yaron; Mary Hynes; Bin Chen; Ami Okada; Susan K McConnell; Helen Rayburn; Marc Tessier-Lavigne
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-29       Impact factor: 11.205

3.  Low level of Hox1.3 gene expression does not preclude the use of promoterless vectors to generate a targeted gene disruption. off.

Authors:  L Jeannotte; J C Ruiz; E J Robertson
Journal:  Mol Cell Biol       Date:  1991-11       Impact factor: 4.272

4.  siRNA as a tool for investigating organogenesis: The pitfalls and the promises.

Authors:  Wen-Chin Lee; Rachel Berry; Peter Hohenstein; Jamie Davies
Journal:  Organogenesis       Date:  2008-07       Impact factor: 2.500

Review 5.  Family matters: How MYC family oncogenes impact small cell lung cancer.

Authors:  Johannes Brägelmann; Stefanie Böhm; Matthew R Guthrie; Gurkan Mollaoglu; Trudy G Oliver; Martin L Sos
Journal:  Cell Cycle       Date:  2017-07-24       Impact factor: 4.534

6.  Dissection of the MYCN locus in Feingold syndrome and isolated oesophageal atresia.

Authors:  Marie Cognet; Agnés Nougayrede; Valérie Malan; Patrick Callier; Celia Cretolle; Laurence Faivre; David Genevieve; Alice Goldenberg; Delphine Heron; Sandra Mercier; Nicole Philip; Sabine Sigaudy; Alain Verloes; Sabine Sarnacki; Arnold Munnich; Michel Vekemans; Stanislas Lyonnet; Heather Etchevers; Jeanne Amiel; Loïc de Pontual
Journal:  Eur J Hum Genet       Date:  2011-01-12       Impact factor: 4.246

Review 7.  Mouse genetics in the 21st century: using gene targeting to create a cornucopia of mouse mutants possessing precise genetic modifications.

Authors:  P J Wilder; A Rizzino
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

8.  Production of calves by transfer of nuclei from cultured inner cell mass cells.

Authors:  M Sims; N L First
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

9.  Targeting of the creatine kinase M gene in embryonic stem cells using isogenic and nonisogenic vectors.

Authors:  J van Deursen; B Wieringa
Journal:  Nucleic Acids Res       Date:  1992-08-11       Impact factor: 16.971

10.  The myc road to hearing restoration.

Authors:  Benjamin Kopecky; Bernd Fritzsch
Journal:  Cells       Date:  2012-09-25       Impact factor: 6.600
  10 in total

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