Literature DB >> 1700957

A human sperm antigen possibly involved in binding and/or fusion with zona-free hamster eggs.

M Okabe1, M Nagira, Y Kawai, S Matzno, T Mimura, T Mayumi.   

Abstract

A monoclonal antibody to human sperm (MH61) was established. The antibody did not attach to ejaculated sperm but to a head region of some sperm that was incubated in medium for 4 to 12 hours. A23187 treatment significantly increased the number of sperm that were reactive to the antibody. When sperm that bound to the zona-free hamster egg were subjected to the indirect immunofluorescence staining, all the sperm reacted to MH61 with their entire head region. The addition of the antibody to the medium before sperm addition reduced the fusion rate of human sperm to zona-free hamster egg.

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Year:  1990        PMID： 1700957     DOI： 10.1016/s0015-0282(16)54015-1

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  12 in total

1.  Identification and characterization of a silencer regulatory element in the 3'-flanking region of the murine CD46 gene.

Authors:  M Nomura; A Tsujimura; N A Begum; M Matsumoto; H Wabiko; K Toyoshima; T Seya
Journal:  Biochem J       Date:  2000-10-15       Impact factor: 3.857

2.  Protein involvement in the fusion between the equatorial segment of acrosome-reacted human spermatozoa and liposomes.

Authors:  E G Arts; J G Wijchman; S Jager; D Hoekstra
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

3.  Molecular cloning of a murine homologue of membrane cofactor protein (CD46): preferential expression in testicular germ cells.

Authors:  A Tsujimura; K Shida; M Kitamura; M Nomura; J Takeda; H Tanaka; M Matsumoto; K Matsumiya; A Okuyama; Y Nishimune; M Okabe; T Seya
Journal:  Biochem J       Date:  1998-02-15       Impact factor: 3.857

Review 4.  The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion.

Authors:  Naokazu Inoue; Masahito Ikawa; Masaru Okabe
Journal:  Asian J Androl       Date:  2010-11-08       Impact factor: 3.285

5.  The complement regulatory proteins CD55 (decay accelerating factor) and CD59 are expressed on the inner acrosomal membrane of human spermatozoa as well as CD46 (membrane cofactor protein).

Authors:  J A Cummerson; B F Flanagan; D G Spiller; P M Johnson
Journal:  Immunology       Date:  2006-07       Impact factor: 7.397

6.  Molecular cloning of membrane cofactor protein (MCP; CD46) on B95a cell, an Epstein-Barr virus-transformed marmoset B cell line: B95a-MCP is susceptible to infection by the CAM, but not the Nagahata strain of the measles virus.

Authors:  Y Murakami; T Seya; M Kurita; A Fukui; S Ueda; S Nagasawa
Journal:  Biochem J       Date:  1998-03-15       Impact factor: 3.857

7.  The CD46 transmembrane domain is required for efficient formation of measles-virus-mediated syncytium.

Authors:  T Seya; M Kurita; K Iwata; Y Yanagi; K Tanaka; K Shida; M Hatanaka; M Matsumoto; S Jun; A Hirano; S Ueda; S Nagasawa
Journal:  Biochem J       Date:  1997-02-15       Impact factor: 3.857

8.  Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm.

Authors:  Naokazu Inoue; Masahito Ikawa; Tomoko Nakanishi; Misako Matsumoto; Midori Nomura; Tsukasa Seya; Masaru Okabe
Journal:  Mol Cell Biol       Date:  2003-04       Impact factor: 4.272

9.  Post-translational modification and intracellular localization of a splice product of CD46 cloned from human testis: role of the intracellular domains in O-glycosylation.

Authors:  T Hara; Y Suzuki; T Nakazawa; H Nishimura; S Nagasawa; M Nishiguchi; M Matsumoto; M Hatanaka; M Kitamura; T Seya
Journal:  Immunology       Date:  1998-04       Impact factor: 7.397

10.  Blocking measles virus infection with a recombinant soluble form of, or monoclonal antibodies against, membrane cofactor protein of complement (CD46).

Authors:  T Seya; M Kurita; T Hara; K Iwata; T Semba; M Hatanaka; M Matsumoto; Y Yanagi; S Ueda; S Nagasawa
Journal:  Immunology       Date:  1995-04       Impact factor: 7.397
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