PURPOSE: The lack of effective systemic therapies for patients with advanced renal cell carcinoma (RCC) has stimulated interest in evaluating novel treatment strategies for this disease. METHODS: This was a two-institution, two-stage, phase II trial of continuous low-dose oral cyclophosphamide (50 mg daily) in combination with celecoxib (400 mg twice daily) in patients with progressive, locally advanced or metastatic RCC. The primary endpoint was disease control rate (DCR) defined as the number of patients with complete (CR) or partial response (PR) or prolonged (> or =6 months) stable disease (SD). Secondary endpoints included time to progression and toxicity. RESULTS: Between May 2001 and January 2003, 36 patients were enrolled onto the trial of which 32 were evaluable for response. One patient had a PR and three others had SD for longer than 6 months (DCR 12.5%, 95% CI 3.5-29.0%). The median progression free survival was 3.5 months (95% CI, 1.9-4.1 months) and the median overall survival was 14.5 months (95% CI, 8.4-20.8 months). One patient experienced grade five gastrointestinal bleeding. Otherwise, the treatment was well tolerated. CONCLUSIONS: Although generally well tolerated, continuous therapy with low-dose cyclophosphamide and celecoxib had limited activity in RCC.
PURPOSE: The lack of effective systemic therapies for patients with advanced renal cell carcinoma (RCC) has stimulated interest in evaluating novel treatment strategies for this disease. METHODS: This was a two-institution, two-stage, phase II trial of continuous low-dose oral cyclophosphamide (50 mg daily) in combination with celecoxib (400 mg twice daily) in patients with progressive, locally advanced or metastatic RCC. The primary endpoint was disease control rate (DCR) defined as the number of patients with complete (CR) or partial response (PR) or prolonged (> or =6 months) stable disease (SD). Secondary endpoints included time to progression and toxicity. RESULTS: Between May 2001 and January 2003, 36 patients were enrolled onto the trial of which 32 were evaluable for response. One patient had a PR and three others had SD for longer than 6 months (DCR 12.5%, 95% CI 3.5-29.0%). The median progression free survival was 3.5 months (95% CI, 1.9-4.1 months) and the median overall survival was 14.5 months (95% CI, 8.4-20.8 months). One patient experienced grade five gastrointestinal bleeding. Otherwise, the treatment was well tolerated. CONCLUSIONS: Although generally well tolerated, continuous therapy with low-dose cyclophosphamide and celecoxib had limited activity in RCC.
Authors: Atsushi Imai; Benjamin D Zeitlin; Fernanda Visioli; Zhihong Dong; Zhaocheng Zhang; Sudha Krishnamurthy; Emily Light; Frank Worden; Shaomeng Wang; Jacques E Nör Journal: Cancer Res Date: 2011-12-08 Impact factor: 12.701
Authors: C London; T Mathie; N Stingle; C Clifford; S Haney; M K Klein; L Beaver; K Vickery; D M Vail; B Hershey; S Ettinger; A Vaughan; F Alvarez; L Hillman; M Kiselow; D Thamm; M L Higginbotham; M Gauthier; E Krick; B Phillips; T Ladue; P Jones; J Bryan; V Gill; A Novasad; L Fulton; J Carreras; C McNeill; C Henry; S Gillings Journal: Vet Comp Oncol Date: 2011-06-01 Impact factor: 2.613
Authors: Christina A To; Robert W Hsieh; James Scott McClellan; Walter Howard; Nancy J Fischbein; Janice M Y Brown; Dean W Felsher; Alice C Fan Journal: BMJ Case Rep Date: 2012-09-07
Authors: Paul L Swiecicki; Emily Bellile; Assuntina G Sacco; Alexander T Pearson; Jeremy M G Taylor; Trachette L Jackson; Douglas B Chepeha; Matthew E Spector; Andrew Shuman; Kelly Malloy; Jeffrey Moyer; Erin McKean; Scott McLean; Ammar Sukari; Gregory T Wolf; Avraham Eisbruch; Mark Prince; Carol Bradford; Thomas E Carey; Shaomeng Wang; Jacques E Nör; Francis P Worden Journal: Invest New Drugs Date: 2016-05-26 Impact factor: 3.850
Authors: Cheryl A London; Heather L Gardner; Tamra Mathie; Nicole Stingle; Roberta Portela; Michael L Pennell; Craig A Clifford; Mona P Rosenberg; David M Vail; Laurel E Williams; Kim L Cronin; Heather Wilson-Robles; Antonella Borgatti; Carolyn J Henry; Dennis B Bailey; Jennifer Locke; Nicole C Northrup; Martin Crawford-Jakubiak; Virginia L Gill; Mary K Klein; David M Ruslander; Doug H Thamm; Brenda Phillips; Gerald Post Journal: PLoS One Date: 2015-04-29 Impact factor: 3.240