Literature DB >> 1700897

The route of non-enzymic and enzymic breakdown of 5-phosphoribosyl 1-pyrophosphate to ribose 1-phosphate.

H Trembacz1, M M Jezewska.   

Abstract

Spontaneous decomposition of 5-phosphoribosyl 1-pyrophosphate at pH 5.5 was established to occur as follows: 5-Phosphoribosyl 1-pyrophosphate----5-phosphoribosyl 1,2-(cyclic)phosphate----ribose 1-phosphate----ribose Enzymic degradation of 5-phosphoribosyl 1-pyrophosphate by alkaline phosphatase from calf intestine and by acid phosphatases from potato and Aspergillus niger was found to proceed according to this pathway within the pH range 2.5-7.4 with accumulation of ribose 1-phosphate. In the case of alkaline phosphatase, Mg2+ ions inhibit the pyrophosphorolysis of 5-phosphoribosyl 1-pyrophosphate and stimulate the hydrolysis of ribose 1-phosphate.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 1700897      PMCID： PMC1149607          DOI： 10.1042/bj2710621

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  A study of the substrate specificity and other properties of the alkaline phosphatase of Escherichia coli.

Authors:  L A HEPPEL; D R HARKNESS; R J HILMOE
Journal:  J Biol Chem       Date:  1962-03       Impact factor: 5.157

2.  Enzymatic synthesis and properties of 5-phosphoribosylpyrophosphate.

Authors:  A KORNBERG; I LIEBERMAN; E S SIMMS
Journal:  J Biol Chem       Date:  1955-07       Impact factor: 5.157

3.  Pyrophosphorylation of ribose 5-phosphate in the enzymatic synthesis of 5-phosphorylribose 1-pyrophosphate.

Authors:  H G KHORANA; J F FERNANDES; A KORNBERG
Journal:  J Biol Chem       Date:  1958-02       Impact factor: 5.157

4.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

5.  A specific enzyme defect in gout associated with overproduction of uric acid.

Authors:  W N Kelley; F M Rosenbloom; J F Henderson; J E Seegmiller
Journal:  Proc Natl Acad Sci U S A       Date:  1967-06       Impact factor: 11.205

6.  Intestinal alkaline phosphatase. Catalytic properties and half of the sites reactivity.

Authors:  D Chappelet-Tordo; M Fosset; M Iwatsubo; C Gache; M Lazdunski
Journal:  Biochemistry       Date:  1974-04-23       Impact factor: 3.162

7.  Phosphoribosylpyrophosphate in erythrocytes of ten mammalian species: concentration, synthesis and degradation.

Authors:  W J Tax; J H Veerkamp
Journal:  Comp Biochem Physiol B       Date:  1978

8.  Mechanism of action of the nonspecific phosphomonoesterase from potatoes.

Authors:  R Y Hsu; W W Cleland; L Anderson
Journal:  Biochemistry       Date:  1966-02       Impact factor: 3.162

9.  Studies on IMP degradation and ribose 1-phosphate utilization in human erythrocytes.

Authors:  S Gini; C Simonelli; P L Ipata
Journal:  Int J Biochem       Date:  1987

10.  GTP depletion and other erythrocyte abnormalities in inherited PNP deficiency.

Authors:  H A Simmonds; A R Watson; D R Webster; A Sahota; D Perrett
Journal:  Biochem Pharmacol       Date:  1982-03-15       Impact factor: 5.858
View more
  2 in total

Review 1.  Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance.

Authors:  Bjarne Hove-Jensen; Kasper R Andersen; Mogens Kilstrup; Jan Martinussen; Robert L Switzer; Martin Willemoës
Journal:  Microbiol Mol Biol Rev       Date:  2016-12-28       Impact factor: 11.056

2.  Modified pathway to synthesize ribulose 1,5-bisphosphate in methanogenic archaea.

Authors:  Michael W Finn; F Robert Tabita
Journal:  J Bacteriol       Date:  2004-10       Impact factor: 3.490
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.