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Literature DB >> 17008409

CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen.

Roland Reibke¹, Natalio Garbi, Ruth Ganss, Günter J Hämmerling, Bernd Arnold, Thilo Oelert.

Abstract

In comparison with CD4+ regulatory T cells, the generation and function of immunomodulatory CD8+T cells is less well defined. Here we describe the existence of regulatory anti-Kb-specific CD8+ T cells that are rendered tolerant during neonatal life via antigen contact exclusively on keratinocytes. These regulatory T cells maintain tolerance during adulthood as they prevent Kb-specific graft rejection by naïve CD8+ T cells. Third-party immune responses remain unaffected. Up-regulation of TGF-beta1 and granzyme B in the regulatory CD8+ T cell population suggests the involvement of these molecules in common suppressive pathways shared with CD4+ regulatory T cells. In summary, CD8+ regulatory T cells can be induced extrathymically through antigen contact on neonatally accessible parenchymal cells and maintain tolerance throughout adult life.

Entities: Gene

Mesh：

Substances：
Autoantigens

Year: 2006 PMID： 17008409 PMCID： PMC1622790 DOI： 10.1073/pnas.0602622103

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

41 in total

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Journal: Proc Natl Acad Sci U S A Date: 1995-08-01 Impact factor: 11.205

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Journal: Int Immunol Date: 1995-02 Impact factor: 4.823

8. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.

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15 in total

Review 1. Regulatory immune cells in transplantation.

Authors: Kathryn J Wood; Andrew Bushell; Joanna Hester
Journal: Nat Rev Immunol Date: 2012-05-25 Impact factor: 53.106

2. Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance.

Authors: Maria Papatriantafyllou; Gerhard Moldenhauer; Julia Ludwig; Anna Tafuri; Natalio Garbi; Gorana Hollmann; Günter Küblbeck; Alexandra Klevenz; Sabine Schmitt; Georg Pougialis; Christof Niehrs; Hermann-Josef Gröne; Gunter J Hämmerling; Bernd Arnold; Thilo Oelert
Journal: Proc Natl Acad Sci U S A Date: 2012-01-17 Impact factor: 11.205

3. Generation and function of immunosuppressive human and murine CD8+ T cells by transforming growth factor-β and retinoic acid.

Authors: Diana Fleissner; Annika Frede; Markus Knott; Torben Knuschke; Robert Geffers; Wiebke Hansen; Gustav Dobos; Jost Langhorst; Jan Buer; Astrid M Westendorf
Journal: Immunology Date: 2011-06-29 Impact factor: 7.397

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Journal: Am J Transplant Date: 2012-06-08 Impact factor: 8.086

CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen.

1. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow.

Review 2. A central role for central tolerance.

3. Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking.

Review 4. Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity.

5. Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype.

6. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction.

7. Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance.

8. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.

9. Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo.

Review 10. Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens.

Review 1. Regulatory immune cells in transplantation.

2. Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance.

3. Generation and function of immunosuppressive human and murine CD8+ T cells by transforming growth factor-β and retinoic acid.

4. Donor-specific CD8+ Foxp3+ T cells protect skin allografts and facilitate induction of conventional CD4+ Foxp3+ regulatory T cells.

Review 5. Dissecting the defects in the neonatal CD8⁺ T-cell response.

6. Local induction of immunosuppressive CD8+ T cells in the gut-associated lymphoid tissues.

7. In vitro induced CD8+ regulatory T cells inhibit skin inflammation.

8. CD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses.

Review 9. Maintaining T cell tolerance of alloantigens: Lessons from animal studies.

Review 10. Promoting transplantation tolerance; adoptive regulatory T cell therapy.

Review 2. A central role for central tolerance.

Review 4. Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity.

Review 10. Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens.

Review 1. Regulatory immune cells in transplantation.

Review 5. Dissecting the defects in the neonatal CD8+ T-cell response.

Review 9. Maintaining T cell tolerance of alloantigens: Lessons from animal studies.

Review 10. Promoting transplantation tolerance; adoptive regulatory T cell therapy.

Review 5. Dissecting the defects in the neonatal CD8⁺ T-cell response.