Literature DB >> 17006870

Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development.

Ulrich Klar1, Bernd Buchmann, Wolfgang Schwede, Werner Skuballa, Jens Hoffmann, Rosemarie B Lichtner.   

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Year:  2006        PMID： 17006870     DOI： 10.1002/anie.200602785

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  27 in total

1.  Design and synthesis of C6-C8 bridged epothilone A.

Authors:  Weiqiang Zhan; Yi Jiang; Peggy J Brodie; David G I Kingston; Dennis C Liotta; James P Snyder
Journal:  Org Lett       Date:  2008-03-21       Impact factor: 6.005

Review 2.  Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

Authors:  Carlo Ballatore; Kurt R Brunden; Donna M Huryn; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith
Journal:  J Med Chem       Date:  2012-09-28       Impact factor: 7.446

Review 3.  Natural products: a continuing source of novel drug leads.

Authors:  Gordon M Cragg; David J Newman
Journal:  Biochim Biophys Acta       Date:  2013-02-18

4.  Phase II trial of sagopilone, a novel epothilone analog in metastatic melanoma.

Authors:  R C DeConti; A P Algazi; S Andrews; P Urbas; O Born; D Stoeckigt; L Floren; J Hwang; J Weber; V K Sondak; A I Daud
Journal:  Br J Cancer       Date:  2010-10-05       Impact factor: 7.640

5.  Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases.

Authors:  Jens Hoffmann; Iduna Fichtner; Margit Lemm; Philip Lienau; Holger Hess-Stumpp; Andrea Rotgeri; Birte Hofmann; Ulrich Klar
Journal:  Neuro Oncol       Date:  2008-09-09       Impact factor: 12.300

Review 6.  Epothilones: tubulin polymerization as a novel target for prostate cancer therapy.

Authors:  James J Lee; W Kevin Kelly
Journal:  Nat Clin Pract Oncol       Date:  2008-12-02

7.  Systemic sagopilone (ZK-EPO) treatment of patients with recurrent malignant gliomas.

Authors:  Antonio Silvani; Paola Gaviani; Anna Fiumani; Vidmer Scaioli; Elena Lamperti; Marica Eoli; Andrea Botturi; Andrea Salmaggi
Journal:  J Neurooncol       Date:  2009-04-21       Impact factor: 4.130

Review 8.  Discovery and development of the epothilones : a novel class of antineoplastic drugs.

Authors:  Hans Reichenbach; Gerhard Höfle
Journal:  Drugs R D       Date:  2008

9.  Weekly administration of sagopilone (ZK-EPO), a fully synthetic epothilone, in patients with refractory solid tumours: results of a phase I trial.

Authors:  D Arnold; W Voigt; P Kiewe; C Behrmann; S Lindemann; S Reif; H Wiesinger; M Giurescu; E Thiel; H-J Schmoll
Journal:  Br J Cancer       Date:  2009-09-22       Impact factor: 7.640

10.  Novel microtubule-targeting agents - the epothilones.

Authors:  Kit L Cheng; Thomas Bradley; Daniel R Budman
Journal:  Biologics       Date:  2008-12
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