| Literature DB >> 17006604 |
Hyo-Bin Kim1, Yong-Chul Lee2, So-Yeon Lee3, Jongsun Jung4, Hyun-Seung Jin1, Ja-Hyeung Kim1, Bong-Seong Kim1, Mi-Jin Kang5, Seong-Ok Jang5, Jihong Kim4, Kuchan Kimm4, Eun-Soon Shin6, Seong-Gene Lee7, Soo-Jong Hong8.
Abstract
Interleukin (IL)-13, which is essential for IgE synthesis, mediates its effects by binding with a receptor composed of IL-4Ralpha and IL-13Ralpha1. We investigated the effects of IL-13 and IL-13Ralpha1 polymorphisms in Korean children with asthma, and whether these have been associated with IgE production. We enrolled 358 atopic asthmatic, 111 non-atopic asthmatic, and 146 non-atopic healthy children. IL-13 and IL-13Ralpha1 genotypes were identified using the PCR-RFLP method. There was an association between the asthma susceptibility and homozygosity for risk allele of IL-13 G+2044A. In children with atopic asthma, risk alleles in IL-13 (A-1512C and C-1112T) and IL-13Ralpha1 (A+1398G) showed increased total IgE (P=0.012, 0.015 and 0.017, respectively). Three-loci haplotype analysis for IL-13 showed that the haplotype composed of -1512C, -1112T and +2044A was associated with higher total IgE than other tested haplotypes in children with atopic asthma (P=0.003). The gene-gene interaction between risk alleles of each IL-13 promoter polymorphism and IL-13Ralpha1 polymorphism was associated with higher total IgE in children with atopic asthma (P=0.002, 0.010). These findings indicate that the IL-13 G+2044A is associated with asthma development and the IL-13 and IL-13Ralpha1 polymorphisms may interact to enhance IgE production.Entities:
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Year: 2006 PMID： 17006604 DOI： 10.1007/s10038-006-0061-x
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172