Literature DB >> 17005840

Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans.

Heidrun Peltroche-Llacsahuanga1, Sophie Goyard, Christophe d'Enfert, Stephan K-H Prill, Joachim F Ernst.   

Abstract

Five isoforms of protein mannosyltransferase (Pmt) O-mannosylate secretory proteins in Candida albicans. pmt mutants were differentially defective for biofilm formation on plastic in static and flow-through systems, and a Pmt inhibitor blocked early stages of biofilm formation. Conceptually, Pmt inhibition may prevent surface anchoring and biofilm-dependent resistance of fungal pathogens.

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Year:  2006        PMID： 17005840      PMCID： PMC1610076          DOI： 10.1128/AAC.00606-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

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Review 3.  O-glycosylation.

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5.  Matrix polymers of Candida biofilms and their possible role in biofilm resistance to antifungal agents.

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  14 in total

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