Literature DB >> 17003510

Leukocyte-specific protein 1 (LSP1): a regulator of leukocyte emigration in inflammation.

Jenny Jongstra-Bilen1, Jan Jongstra.   

Abstract

LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficient mouse strain and in this review we describe our findings together with those of other investigators. The results show a complex function of LSP1 in regulating leukocyte recruitment to inflamed sites. Based on current evidence, we propose that the levels of LSP1 on the cytoskeleton and the type of integrin involved are some of the critical elements which affect LSP1 function in modulating the threshold for transmigration.

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Year:  2006        PMID： 17003510     DOI： 10.1385/IR:35:1:65

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  51 in total

1.  Lymphocyte-specific Ca2+-binding protein LSP1 is associated with the cytoplasmic face of the plasma membrane.

Authors:  D P Klein; J Jongstra-Bilen; K Ogryzlo; R Chong; J Jongstra
Journal:  Mol Cell Biol       Date:  1989-07       Impact factor: 4.272

2.  Leukocyte-specific gene 1 protein (LSP1) is involved in chemokine KC-activated cytoskeletal reorganization in murine neutrophils in vitro.

Authors:  M Hannigan; L Zhan; Y Ai; C K Huang
Journal:  J Leukoc Biol       Date:  2001-03       Impact factor: 4.962

3.  Lymphocyte-specific protein 1: a specific marker of human leucocytes.

Authors:  K Pulford; M Jones; A H Banham; E Haralambieva; D Y Mason
Journal:  Immunology       Date:  1999-02       Impact factor: 7.397

4.  A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation.

Authors:  A Coxon; P Rieu; F J Barkalow; S Askari; A H Sharpe; U H von Andrian; M A Arnaout; T N Mayadas
Journal:  Immunity       Date:  1996-12       Impact factor: 31.745

5.  Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chain.

Authors:  Hongwei Qin; Jeffrey C Edberg; Andrew W Gibson; Grier P Page; Lihong Teng; Robert P Kimberly
Journal:  J Immunol       Date:  2004-11-15       Impact factor: 5.422

6.  LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils.

Authors:  C K Huang; L Zhan; Y Ai; J Jongstra
Journal:  J Biol Chem       Date:  1997-01-03       Impact factor: 5.157

7.  LSP1 modulates leukocyte populations in resting and inflamed peritoneum.

Authors:  J Jongstra-Bilen; V L Misener; C Wang; H Ginzberg; A Auerbach; A L Joyner; G P Downey; J Jongstra
Journal:  Blood       Date:  2000-09-01       Impact factor: 22.113

8.  Human and mouse LSP1 genes code for highly conserved phosphoproteins.

Authors:  J Jongstra-Bilen; A J Young; R Chong; J Jongstra
Journal:  J Immunol       Date:  1990-02-01       Impact factor: 5.422

9.  Modulation of Mac-1 (CD11b/CD18)-mediated adhesion by the leukocyte-specific protein 1 is key to its role in neutrophil polarization and chemotaxis.

Authors:  Chunjie Wang; Hisayoshi Hayashi; Rene Harrison; Basil Chiu; Jason R Chan; Hanne L Ostergaard; Robert D Inman; Jan Jongstra; Myron I Cybulsky; Jenny Jongstra-Bilen
Journal:  J Immunol       Date:  2002-07-01       Impact factor: 5.422

10.  LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration.

Authors:  Lixin Liu; Denise C Cara; Jaswinder Kaur; Eko Raharjo; Sarah C Mullaly; Jenny Jongstra-Bilen; Jan Jongstra; Paul Kubes
Journal:  J Exp Med       Date:  2005-01-31       Impact factor: 14.307
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Authors:  Yali Hou; George E Liu; Derek M Bickhart; Lakshmi K Matukumalli; Congjun Li; Jiuzhou Song; Louis C Gasbarre; Curtis P Van Tassell; Tad S Sonstegard
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Authors:  A Hein; B Rack; L Li; A B Ekici; A Reis; M P Lux; J M Cunningham; M Rübner; B L Fridley; A Schneeweiss; H Tesch; W Lichtenegger; T Fehm; G Heinrich; M Rezai; M W Beckmann; W Janni; R M Weinshilboum; L Wang; P A Fasching; L Häberle
Journal:  Geburtshilfe Frauenheilkd       Date:  2017-06-28       Impact factor: 2.915

Review 4.  DNA methylation and differentiation: silencing, upregulation and modulation of gene expression.

Authors:  Melanie Ehrlich; Michelle Lacey
Journal:  Epigenomics       Date:  2013       Impact factor: 4.778

5.  Lymphocyte-specific protein 1 (LSP1) regulates bone marrow stromal cell antigen 2 (BST-2)-mediated intracellular trafficking of HIV-1 in dendritic cells.

Authors:  Rutuja Kulkarni; Shuxian Jiang; Gabriel Birrane; Anil Prasad
Journal:  FEBS Lett       Date:  2020-04-28       Impact factor: 4.124

6.  RUNX1 regulates site specificity of DNA demethylation by recruitment of DNA demethylation machineries in hematopoietic cells.

Authors:  Takahiro Suzuki; Yuri Shimizu; Erina Furuhata; Shiori Maeda; Mami Kishima; Hajime Nishimura; Saaya Enomoto; Yoshihide Hayashizaki; Harukazu Suzuki
Journal:  Blood Adv       Date:  2017-09-06

7.  Leukocyte-specific protein 1: a novel regulator of hepatocellular proliferation and migration deleted in human hepatocellular carcinoma.

Authors:  Kelly Koral; Shirish Paranjpe; William C Bowen; Wendy Mars; Jianhua Luo; George K Michalopoulos
Journal:  Hepatology       Date:  2014-12-24       Impact factor: 17.425

8.  Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages.

Authors:  Amy L Sullivan; Christopher Benner; Sven Heinz; Wendy Huang; Lan Xie; Joseph M Miano; Christopher K Glass
Journal:  Mol Cell Biol       Date:  2010-12-06       Impact factor: 4.272

9.  Leukocyte-specific protein 1 regulates neutrophil recruitment in acute lung inflammation.

Authors:  Nguyen Phuong Khanh Le; Shankaramurthy Channabasappa; Mokarram Hossain; Lixin Liu; Baljit Singh
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2015-08-28       Impact factor: 5.464

10.  HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1.

Authors:  Appakkudal R Anand; Anil Prasad; Ritu R Bradley; Yadwinder S Deol; Tirumuru Nagaraja; Xianghui Ren; Ernest F Terwilliger; Ramesh K Ganju
Journal:  Blood       Date:  2009-08-21       Impact factor: 22.113
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