Literature DB >> 17002980

Sensorineural hearing loss: potential therapies and gene targets for drug development.

Louisa S Tang1, Celina Montemayor, Fred A Pereira.   

Abstract

Recent advances in the developmental biology, genetics and cell biology of the inner ear are guiding research to novel therapeutic modalities - a market currently estimated to be at least US Dollars 10 billion. This article highlights prospects to manipulate the mammalian hearing organ with gene and stem cell delivery to the inner ear to protect, repair or regenerate the hair cells, supporting cells and associated nerves.

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Year:  2006        PMID： 17002980     DOI： 10.1080/15216540600913258

Source DB:  PubMed          Journal:  IUBMB Life        ISSN： 1521-6543            Impact factor:   3.885


  4 in total

1.  In Vivo Calcium Imaging of Lateral-line Hair Cells in Larval Zebrafish.

Authors:  Daria Lukasz; Katie S Kindt
Journal:  J Vis Exp       Date:  2018-11-28       Impact factor: 1.355

2.  Localized cell and drug delivery for auditory prostheses.

Authors:  Jeffrey L Hendricks; Jennifer A Chikar; Mark A Crumling; Yehoash Raphael; David C Martin
Journal:  Hear Res       Date:  2008-06-07       Impact factor: 3.208

Review 3.  Development and regeneration of the inner ear.

Authors:  Tao Kwan; Patricia M White; Neil Segil
Journal:  Ann N Y Acad Sci       Date:  2009-07       Impact factor: 5.691

4.  A coregulatory network of NR2F1 and microRNA-140.

Authors:  David Y Chiang; David W Cuthbertson; Fernanda R Ruiz; Na Li; Fred A Pereira
Journal:  PLoS One       Date:  2013-12-03       Impact factor: 3.240
  4 in total

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