Literature DB >> 17002215

Eating, sleeping and rewarding: orexin receptors and their antagonists.

Matilda J Bingham1, Jiaqiang Cai, Maureen R Deehan.   

Abstract

The orexin system plays a key role in the control of eating, sleeping and rewarding. This review summarizes the latest developments in the identification of orexin receptor antagonists. By using a selective orexin-1 receptor antagonist, SB-334867-A (GlaxoSnzithKline plc), the in vivo futctions of both the orexin-1 and orexin-2 receptors have been elucidated. This review also sunmmarizes the literature and current opinions up to May 2006 on the therapeutic utility of orexin receptor antagonists for the treatment of eating disorders, sleeping disorders and drug addiction.

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Year:  2006        PMID： 17002215

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN： 1367-6733


  9 in total

1.  Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.

Authors:  Tian-Rui Xu; Richard J Ward; John D Pediani; Graeme Milligan
Journal:  J Biol Chem       Date:  2012-03-02       Impact factor: 5.157

2.  Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.

Authors:  Richard J Ward; John D Pediani; Graeme Milligan
Journal:  Br J Pharmacol       Date:  2011-03       Impact factor: 8.739

Review 3.  Orphan GPCR research.

Authors:  S Chung; T Funakoshi; O Civelli
Journal:  Br J Pharmacol       Date:  2007-12-10       Impact factor: 8.739

4.  Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists.

Authors:  Rong Jiang; Xinyi Song; Purva Bali; Anthony Smith; Claudia Ruiz Bayona; Li Lin; Michael D Cameron; Patricia H McDonald; Paul J Kenny; Theodore M Kamenecka
Journal:  Bioorg Med Chem Lett       Date:  2012-05-04       Impact factor: 2.823

5.  Synthesis and characterization of a new Positron emission tomography probe for orexin 2 receptors neuroimaging.

Authors:  Ping Bai; Yan Liu; Yulong Xu; Robin Striar; Gengyang Yuan; Sepideh Afshar; Amelia G Langan; Anna K Rattray; Changning Wang
Journal:  Bioorg Chem       Date:  2022-04-04       Impact factor: 5.307

Review 6.  The orexins/hypocretins and schizophrenia.

Authors:  Ariel Y Deutch; Michael Bubser
Journal:  Schizophr Bull       Date:  2007-08-28       Impact factor: 9.306

7.  In vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide S.

Authors:  Valeria Camarda; Anna Rizzi; Chiara Ruzza; Silvia Zucchini; Giuliano Marzola; Erika Marzola; Remo Guerrini; Severo Salvadori; Rainer K Reinscheid; Domenico Regoli; Girolamo Calò
Journal:  J Pharmacol Exp Ther       Date:  2008-10-29       Impact factor: 4.030

8.  Neuroendocrine proopiomelanocortin neurons are excited by hypocretin/orexin.

Authors:  Claudio Acuna-Goycolea; Anthony N van den Pol
Journal:  J Neurosci       Date:  2009-02-04       Impact factor: 6.167

9.  A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging.

Authors:  Ping Bai; Sha Bai; Michael S Placzek; Xiaoxia Lu; Stephanie A Fiedler; Brenda Ntaganda; Hsiao-Ying Wey; Changning Wang
Journal:  Molecules       Date:  2020-02-25       Impact factor: 4.411
  9 in total

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