| Literature DB >> 17000982 |
A Petzold1, N Hinds, N M F Murray, N P Hirsch, D Grant, G Keir, E J Thompson, M M Reilly.
Abstract
Long-term morbidity from Guillain-Barré syndrome (GBS) is caused by axonal damage. This prospective study demonstrated that neurofilaments (NfHs), a biomarker for axonal damage, were of prognostic value in GBS. CSF NfH levels correlated with the F score and Medical Research Council summed score and were higher in patients with neurophysiologic evidence of axonal degeneration compared to those without. Pathologically high CSF NfH levels (>0.73 ng/mL) predicted worse motor and functional outcome.Entities:
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Year: 2006 PMID： 17000982 DOI： 10.1212/01.wnl.0000237334.69665.92
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910