Literature DB >> 17000815

Integrating the science of consciousness and anesthesia.

George A Mashour1.   

Abstract

The nature and mechanism of human consciousness is emerging as one of the most important scientific and philosophical questions of the 21st century. Disregarded as a subject of serious inquiry throughout most of the 20th century, it has now regained legitimacy as a scientific endeavor. The investigation of consciousness and the mechanisms of general anesthesia have begun to converge. In the present article I provide an introduction to the study of consciousness, describe the neural correlates of consciousness that may be targets of general anesthetics, and suggest an integrated approach to the science of consciousness and anesthesia.

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Year:  2006        PMID: 17000815     DOI: 10.1213/01.ane.0000232442.69757.4a

Source DB:  PubMed          Journal:  Anesth Analg        ISSN: 0003-2999            Impact factor:   5.108


  37 in total

1.  Propofol disrupts functional interactions between sensory and high-order processing of auditory verbal memory.

Authors:  Xiaolin Liu; Kathryn K Lauer; Barney D Ward; Stephen M Rao; Shi-Jiang Li; Anthony G Hudetz
Journal:  Hum Brain Mapp       Date:  2011-09-20       Impact factor: 5.038

Review 2.  General anesthesia and altered states of arousal: a systems neuroscience analysis.

Authors:  Emery N Brown; Patrick L Purdon; Christa J Van Dort
Journal:  Annu Rev Neurosci       Date:  2011       Impact factor: 12.449

3.  Synthetic consciousness: the distributed adaptive control perspective.

Authors:  Paul F M J Verschure
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-08-19       Impact factor: 6.237

Review 4.  Neurochemical modulators of sleep and anesthetic states.

Authors:  Christa J Van Dort; Helen A Baghdoyan; Ralph Lydic
Journal:  Int Anesthesiol Clin       Date:  2008

5.  Altered temporal variance and neural synchronization of spontaneous brain activity in anesthesia.

Authors:  Zirui Huang; Zhiyao Wang; Jianfeng Zhang; Rui Dai; Jinsong Wu; Yuan Li; Weimin Liang; Ying Mao; Zhong Yang; Giles Holland; Jun Zhang; Georg Northoff
Journal:  Hum Brain Mapp       Date:  2014-05-28       Impact factor: 5.038

6.  Preferential effect of isoflurane on top-down vs. bottom-up pathways in sensory cortex.

Authors:  Aeyal Raz; Sean M Grady; Bryan M Krause; Daniel J Uhlrich; Karen A Manning; Matthew I Banks
Journal:  Front Syst Neurosci       Date:  2014-10-07

7.  Differential effects of deep sedation with propofol on the specific and nonspecific thalamocortical systems: a functional magnetic resonance imaging study.

Authors:  Xiaolin Liu; Kathryn K Lauer; B Douglas Ward; Shi-Jiang Li; Anthony G Hudetz
Journal:  Anesthesiology       Date:  2013-01       Impact factor: 7.892

8.  BOLD fMRI in infants under sedation: Comparing the impact of pentobarbital and propofol on auditory and language activation.

Authors:  Mark W DiFrancesco; Sara A Robertson; Prasanna Karunanayaka; Scott K Holland
Journal:  J Magn Reson Imaging       Date:  2013-03-22       Impact factor: 4.813

9.  The thalamus and brainstem act as key hubs in alterations of human brain network connectivity induced by mild propofol sedation.

Authors:  Tommaso Gili; Neeraj Saxena; Ana Diukova; Kevin Murphy; Judith E Hall; Richard G Wise
Journal:  J Neurosci       Date:  2013-02-27       Impact factor: 6.167

10.  Distinctive recruitment of endogenous sleep-promoting neurons by volatile anesthetics and a nonimmobilizer.

Authors:  Bo Han; Hilary S McCarren; Dan O'Neill; Max B Kelz
Journal:  Anesthesiology       Date:  2014-11       Impact factor: 7.892

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