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Literature DB >> 17000747

Resistance mechanisms in an in vitro-selected amoxicillin-resistant strain of Helicobacter pylori.

Abstract

We investigated the beta-lactam resistance mechanism(s) of an in vitro-selected amoxicillin-resistant Helicobacter pylori strain (AmoxR). Our results demonstrated that resistance is due to a combination of amino acid substitutions in penicillin binding protein 1 (PBP1), HopB, and HopC identified in AmoxR, resulting in decreased affinity of PBP1 for amoxicillin and decreased accumulation of penicillin.

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Year: 2006 PMID： 17000747 PMCID： PMC1694008 DOI： 10.1128/AAC.00759-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

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Journal: J Antimicrob Chemother Date: 2002-12 Impact factor: 5.790

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Journal: J Antimicrob Chemother Date: 2000-05 Impact factor: 5.790

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Authors: R Paul; S Postius; K Melchers; K P Schäfer
Journal: Antimicrob Agents Chemother Date: 2001-03 Impact factor: 5.191

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Authors: C R DeLoney; N L Schiller
Journal: Antimicrob Agents Chemother Date: 2000-12 Impact factor: 5.191

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Journal: Clin Microbiol Rev Date: 1997-10 Impact factor: 26.132

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Authors: M M Exner; P Doig; T J Trust; R E Hancock
Journal: Infect Immun Date: 1995-04 Impact factor: 3.441

9. Alterations in penicillin-binding protein 1A confer resistance to beta-lactam antibiotics in Helicobacter pylori.

Authors: M M Gerrits; D Schuijffel; A A van Zwet; E J Kuipers; C M J E Vandenbroucke-Grauls; J G Kusters
Journal: Antimicrob Agents Chemother Date: 2002-07 Impact factor: 5.191

10. Antimicrobial resistance incidence and risk factors among Helicobacter pylori-infected persons, United States.

Authors: William M Duck; Jeremy Sobel; Janet M Pruckler; Qunsheng Song; David Swerdlow; Cindy Friedman; Alana Sulka; Balasubra Swaminathan; Tom Taylor; Mike Hoekstra; Patricia Griffin; Duane Smoot; Rick Peek; David C Metz; Peter B Bloom; Steven Goldschmidt; Julie Parsonnet; George Triadafilopoulos; Guillermo I Perez-Perez; Nimish Vakil; Peter Ernst; Steve Czinn; Donald Dunne; Ben D Gold
Journal: Emerg Infect Dis Date: 2004-06 Impact factor: 6.883

11 in total

1. Mechanisms of Helicobacter pylori antibiotic resistance: An updated appraisal.

Authors: Vincenzo De Francesco; Angelo Zullo; Cesare Hassan; Floriana Giorgio; Rosa Rosania; Enzo Ierardi
Journal: World J Gastrointest Pathophysiol Date: 2011-06-15

2. Who's Winning the War? Molecular Mechanisms of Antibiotic Resistance in Helicobacter pylori.

Authors: Kathleen R Jones; Jeong-Heon Cha; D Scott Merrell
Journal: Curr Drug ther Date: 2008-09-01

3. Antibacterial activities of liposomal linolenic acids against antibiotic-resistant Helicobacter pylori.

Authors: Marygorret Obonyo; Li Zhang; Soracha Thamphiwatana; Dissaya Pornpattananangkul; Victoria Fu; Liangfang Zhang
Journal: Mol Pharm Date: 2012-08-06 Impact factor: 4.939

4. Contribution of specific amino acid changes in penicillin binding protein 1 to amoxicillin resistance in clinical Helicobacter pylori isolates.

Authors: Nadia N Qureshi; Dimitrios Morikis; Neal L Schiller
Journal: Antimicrob Agents Chemother Date: 2010-10-18 Impact factor: 5.191

5. Substitutions in penicillin-binding protein 1 in amoxicillin-resistant Helicobacter pylori strains isolated from Korean patients.

Authors: Beom Jin Kim; Jae G Kim
Journal: Gut Liver Date: 2013-08-14 Impact factor: 4.519

6. A Newly Discovered Drug Resistance Gene rfaF In Helicobacter pylori.

Authors: Jiansheng Lin; Xiaoyan Zhang; Yancheng Wen; Hao Chen; Feifei She
Journal: Infect Drug Resist Date: 2019-11-12 Impact factor: 4.003

7. Antimicrobial resistance patterns and genetic elements associated with the antibiotic resistance of Helicobacter pylori strains from Shanghai.

Authors: Yixin Liu; Su Wang; Feng Yang; Wenjing Chi; Li Ding; Tao Liu; Feng Zhu; Danian Ji; Jun Zhou; Yi Fang; Jinghao Zhang; Ping Xiang; Yanmei Zhang; Hu Zhao
Journal: Gut Pathog Date: 2022-03-30 Impact factor: 4.181