Literature DB >> 16998621

Molecular biology of hepatitis B virus: effect of nucleotide substitutions on the clinical features of chronic hepatitis B.

Osamu Yokosuka1, Makoto Arai.   

Abstract

Hepatitis B virus (HBV) is a major cause of liver disease worldwide. It is covered with envelope (surface antigen) proteins with the nucleocapsid (core antigen) inside. In the nucleocapsid, there is an incomplete double-stranded DNA and a DNA polymerase. Four genes, S, C, X, and P, are encoded, and these partially overlap. Mutations have been reported in each gene and in their promoter regions, and these mutations can change the efficiency of HBV replication and the clinical course of patients. In this article, we review the relationship between the molecular biology of HBV and its clinical outcome.

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Year:  2006        PMID： 16998621     DOI： 10.1007/s00795-006-0328-5

Source DB:  PubMed          Journal:  Med Mol Morphol        ISSN： 1860-1499            Impact factor:   2.309


  71 in total

1.  Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy.

Authors:  J F Conway; N Cheng; A Zlotnick; P T Wingfield; S J Stahl; A C Steven
Journal:  Nature       Date:  1997-03-06       Impact factor: 49.962

2.  Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes.

Authors:  Hui-Ching Wang; Wen-Tsan Chang; Wen-Wei Chang; Han-Chieh Wu; Wenya Huang; Huan-Yao Lei; Ming-Derg Lai; Nelson Fausto; Ih-Jen Su
Journal:  Hepatology       Date:  2005-04       Impact factor: 17.425

3.  Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC).

Authors:  K Das; X Xiong; H Yang; C E Westland; C S Gibbs; S G Sarafianos; E Arnold
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

Review 4.  Hepatic purine and pyrimidine metabolism: implications for antiviral chemotherapy of viral hepatitis.

Authors:  T Shaw; S A Locarnini
Journal:  Liver       Date:  1995-08

5.  Detection of mutations in the enhancer 2/core promoter region of hepatitis B virus in patients with chronic hepatitis B virus infection: comparison with mutations in precore and core regions in relation to clinical status.

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Journal:  J Med Virol       Date:  1999-04       Impact factor: 2.327

6.  Factors associated with hepatitis B virus DNA breakthrough in patients receiving prolonged lamivudine therapy.

Authors:  M F Yuen; E Sablon; C K Hui; H J Yuan; H Decraemer; C L Lai
Journal:  Hepatology       Date:  2001-10       Impact factor: 17.425

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Authors:  E Hildt; G Saher; V Bruss; P H Hofschneider
Journal:  Virology       Date:  1996-11-01       Impact factor: 3.616

8.  Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication.

Authors:  V E Buckwold; Z Xu; T S Yen; J H Ou
Journal:  J Gen Virol       Date:  1997-08       Impact factor: 3.891

9.  Hypermodification and immune escape of an internally deleted middle-envelope (M) protein of frequent and predominant hepatitis B virus variants.

Authors:  Pei-Ching Tai; Fat-Moon Suk; Wolfram H Gerlich; A Robert Neurath; Chiaho Shih
Journal:  Virology       Date:  2002-01-05       Impact factor: 3.616

10.  Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.

Authors:  H Huang; R Chopra; G L Verdine; S C Harrison
Journal:  Science       Date:  1998-11-27       Impact factor: 47.728
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  10 in total

1.  The analysis of correlation between IL-12 gene expression and hepatitis B virus in the affected patients.

Authors:  Abdolhossein Zare; Ahmad Rashki; Sajjad Ghahari; Bashir Ghayoori
Journal:  Virusdisease       Date:  2015-07-07

2.  Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment.

Authors:  Jianhua Li; Yinghui Liu; Zekun Wang; Kuancheng Liu; Yaohui Wang; Jiangxia Liu; Huanping Ding; Zhenghong Yuan
Journal:  J Virol       Date:  2011-04-20       Impact factor: 5.103

3.  Hepatitis B virus infection in post-vaccination South Africa: occult HBV infection and circulating surface gene variants.

Authors:  Edina Amponsah-Dacosta; Ramokone L Lebelo; J Nare Rakgole; Selokela G Selabe; Maemu P Gededzha; Simnikiwe H Mayaphi; Eleanor A Powell; Jason T Blackard; M Jeffrey Mphahlele
Journal:  J Clin Virol       Date:  2014-12-03       Impact factor: 3.168

Review 4.  Hepatitis B virus (HBV) and autoimmune disease.

Authors:  Ram Maya; M Eric Gershwin; Yehuda Shoenfeld
Journal:  Clin Rev Allergy Immunol       Date:  2008-02       Impact factor: 8.667

5.  Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients.

Authors:  Masashi Tatsukawa; Akinobu Takaki; Hidenori Shiraha; Kazuko Koike; Yoshiaki Iwasaki; Haruhiko Kobashi; Shin-Ichi Fujioka; Kohsaku Sakaguchi; Kazuhide Yamamoto
Journal:  BMC Cancer       Date:  2011-10-21       Impact factor: 4.430

6.  Epigenetic mechanisms in virus-induced tumorigenesis.

Authors:  Elzbieta Poreba; Justyna Karolina Broniarczyk; Anna Gozdzicka-Jozefiak
Journal:  Clin Epigenetics       Date:  2011-03-23       Impact factor: 6.551

7.  HBV Core Protein Enhances Cytokine Production.

Authors:  Tatsuo Kanda; Shuang Wu; Reina Sasaki; Masato Nakamura; Yuki Haga; Xia Jiang; Shingo Nakamoto; Osamu Yokosuka
Journal:  Diseases       Date:  2015-09-17

8.  Development of a sensitive enzyme-linked immunosorbent assay for detection of hepatitis B surface antigen using novel monoclonal antibodies.

Authors:  Yaghoub Yazdani; Azam Roohi; Jalal Khoshnoodi; Fazel Shokri
Journal:  Avicenna J Med Biotechnol       Date:  2010-10

Review 9.  Modulation of the unfolded protein response by the human hepatitis B virus.

Authors:  Catalin Lazar; Mihaela Uta; Norica Branza-Nichita
Journal:  Front Microbiol       Date:  2014-08-19       Impact factor: 5.640

10.  Molecular Epidemiology of Hepatitis B Virus in Turkish Cypriot.

Authors:  Unal Sumer; Murat Sayan
Journal:  Pol J Microbiol       Date:  2019-10-22
  10 in total

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