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Literature DB >> 16998481

NMDA receptors are critical for unleashing consolidated auditory fear memories.

Cyrinne Ben Mamou¹, Karine Gamache, Karim Nader.

Abstract

Memories are dynamic and can change when recalled. The process that returns memories to a labile state during remembering is unclear. We found that the presence of NMDA, but not AMPA, receptor antagonists in the amygdala prior to recall prevented the consolidated fear memory from returning to a labile state. These findings suggest that NMDA receptors in the amygdala are critical for transforming a memory from a fixed to a labile state.

Entities: Chemical Disease

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Year: 2006 PMID： 16998481 DOI： 10.1038/nn1778

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

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Cited

132 in total

1. Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin.

Authors: Janine L Kwapis; Timothy J Jarome; Janet C Schiff; Fred J Helmstetter
Journal: Learn Mem Date: 2011-10-25 Impact factor: 2.460

2. Sleep-dependent declarative memory consolidation--unaffected after blocking NMDA or AMPA receptors but enhanced by NMDA coagonist D-cycloserine.

Authors: Gordon B Feld; Tanja Lange; Steffen Gais; Jan Born
Journal: Neuropsychopharmacology Date: 2013-07-26 Impact factor: 7.853

3. The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation.

Authors: Timothy J Jarome; Janine L Kwapis; Craig T Werner; Ryan G Parsons; Georgette M Gafford; Fred J Helmstetter
Journal: Learn Mem Date: 2012-06-20 Impact factor: 2.460

Review 4. Reconsolidation and the Dynamic Nature of Memory.

Authors: Karim Nader
Journal: Cold Spring Harb Perspect Biol Date: 2015-09-09 Impact factor: 10.005

5. Memories reactivated under ketamine are subsequently stronger: A potential pre-clinical behavioral model of psychosis.

Authors: Michael J Honsberger; Jane R Taylor; Philip R Corlett
Journal: Schizophr Res Date: 2015-02-24 Impact factor: 4.939

6. The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats.

Authors: Travis E Brown; Brian R Lee; Barbara A Sorg
Journal: Learn Mem Date: 2008-12-02 Impact factor: 2.460

NMDA receptors are critical for unleashing consolidated auditory fear memories.

1. Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin.

2. Sleep-dependent declarative memory consolidation--unaffected after blocking NMDA or AMPA receptors but enhanced by NMDA coagonist D-cycloserine.

3. The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation.

Review 4. Reconsolidation and the Dynamic Nature of Memory.

5. Memories reactivated under ketamine are subsequently stronger: A potential pre-clinical behavioral model of psychosis.

6. The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats.

7. DNA methyltransferase activity is required for memory-related neural plasticity in the lateral amygdala.

8. Activation of GSK3β induced by recall of cocaine reward memories is dependent on GluN2A/B NMDA receptor signaling.

9. Cellular and systems mechanisms of memory strength as a constraint on auditory fear reconsolidation.

10. Glucocorticoid receptor antagonism disrupts the reconsolidation of social reward-related memories in rats.