AIM: The purpose of this study is to determine the effect following exercise to exhaustion of vitamin E supplementation on oxidative stress in athletic students. METHODS:Twenty male students voluntarily participated in the study and were randomly assigned (double blind) to either a vitamin E (daily dose of 450 mg of a-tocopherol for a period of 8 weeks) or a placebo group (took capsules containing 450 mg of lactose for 8 weeks). Before and after 8 weeks blood samples were collected at rest and after exercise to exhaustion. Oxidative stress markers were malondialdehyde (MDA), carbonylated proteins (CP) and creatine kinase (CK). Also, the effect of vitamin E on ergometer cycling time, as an example of endurance performance, was evaluated. RESULTS: ANOVA and independent t-tests indicated that vitamin E supplementation did not significantly change (P > 0.05) MDA, CP and CK values at rest, after exercise to exhaustion, and cycling time, but plasma volume after exercise to exhaustion significantly decreased (P < 0.05). CONCLUSIONS: Although vitamin E supplementation had no effect on exercise performance or capacity in athletic students, further investigation is required using larger numbers of subjects and measures of vitamin E before unequivocal conclusion can be stated.
RCT Entities:
AIM: The purpose of this study is to determine the effect following exercise to exhaustion of vitamin E supplementation on oxidative stress in athletic students. METHODS: Twenty male students voluntarily participated in the study and were randomly assigned (double blind) to either a vitamin E (daily dose of 450 mg of a-tocopherol for a period of 8 weeks) or a placebo group (took capsules containing 450 mg of lactose for 8 weeks). Before and after 8 weeks blood samples were collected at rest and after exercise to exhaustion. Oxidative stress markers were malondialdehyde (MDA), carbonylated proteins (CP) and creatine kinase (CK). Also, the effect of vitamin E on ergometer cycling time, as an example of endurance performance, was evaluated. RESULTS: ANOVA and independent t-tests indicated that vitamin E supplementation did not significantly change (P > 0.05) MDA, CP and CK values at rest, after exercise to exhaustion, and cycling time, but plasma volume after exercise to exhaustion significantly decreased (P < 0.05). CONCLUSIONS: Although vitamin E supplementation had no effect on exercise performance or capacity in athletic students, further investigation is required using larger numbers of subjects and measures of vitamin E before unequivocal conclusion can be stated.
Authors: Goran Bjelakovic; Dimitrinka Nikolova; Lise Lotte Gluud; Rosa G Simonetti; Christian Gluud Journal: Cochrane Database Syst Rev Date: 2012-03-14
Authors: Michalis G Nikolaidis; Chad M Kerksick; Manfred Lamprecht; Steven R McAnulty Journal: Oxid Med Cell Longev Date: 2012-08-13 Impact factor: 6.543