Literature DB >> 1699812

Signal transduction in human monocytes and granulocytes through the PI-linked antigen CD14.

F Lund-Johansen1, J Olweus, A Aarli, R Bjerknes.   

Abstract

A possible role for the PI-linked CD14 molecule in human monocyte and granulocyte signal mediation was investigated. Using flow cytometry and the fluorescent indicators Fluo-3 and dihydrorhodamine-123 it was shown that crosslinking of the CD14 molecule induces an increase in monocyte and granulocyte cytoplasmic calcium concentration and monocyte H2O2 production. These responses were found to be independent of IgG Fc receptors and suggest an intrinsic signal mediating capacity of the CD14 molecule.

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Year:  1990        PMID： 1699812     DOI： 10.1016/0014-5793(90)81049-t

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  Phenotypic markers of alveolar macrophage maturation in pulmonary sarcoidosis.

Authors:  I Stríz; Y M Wang; H Teschler; C Sorg; U Costabel
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2.  Role of calcium during lipopolysaccharide stimulation of neutrophils.

Authors:  D A Rodeberg; G F Babcock
Journal:  Infect Immun       Date:  1996-07       Impact factor: 3.441

3.  Expression of adhesion molecules on granulocytes and monocytes from patients with asthma stimulated in vitro with interleukin-8 and monocyte chemotactic protein-1.

Authors:  E M Verdegaal; S T Zegveld; I Blokland; H Beekhuizen; W Bakker; L N Willems; R van Furth
Journal:  Inflammation       Date:  1998-04       Impact factor: 4.092

4.  Cell activation mediated by glycosylphosphatidylinositol-anchored or transmembrane forms of CD14.

Authors:  J Pugin; V V Kravchenko; J D Lee; L Kline; R J Ulevitch; P S Tobias
Journal:  Infect Immun       Date:  1998-03       Impact factor: 3.441

5.  Heterogeneity in Lewis-X and sialyl-Lewis-X antigen expression on monocytes in whole blood: relation to stimulus-induced oxidative burst.

Authors:  C Elbim; J Hakim; M A Gougerot-Pocidalo
Journal:  Am J Pathol       Date:  1998-04       Impact factor: 4.307

6.  Granulocyte-macrophage colony-stimulating factor down-regulates CD14 expression on monocytes.

Authors:  M Kruger; J G Van de Winkel; T P De Wit; L Coorevits; J L Ceuppens
Journal:  Immunology       Date:  1996-09       Impact factor: 7.397

7.  Neisserial porins inhibit human neutrophil actin polymerization, degranulation, opsonin receptor expression, and phagocytosis but prime the neutrophils to increase their oxidative burst.

Authors:  R Bjerknes; H K Guttormsen; C O Solberg; L M Wetzler
Journal:  Infect Immun       Date:  1995-01       Impact factor: 3.441

8.  Evaluation of soluble CD 14 and neopterin as serum parameters of the inflammatory activity of pulmonary sarcoidosis.

Authors:  J Homolka; J Lorenz; H D Zuchold; J Müller-Quernheim
Journal:  Clin Investig       Date:  1992-10

9.  Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2.

Authors:  M E Doerfler; J Weiss; J D Clark; P Elsbach
Journal:  J Clin Invest       Date:  1994-04       Impact factor: 14.808

10.  Regulated Ca2+ signalling through leukocyte CD11b/CD18 integrin.

Authors:  D C Altieri; S J Stamnes; C G Gahmberg
Journal:  Biochem J       Date:  1992-12-01       Impact factor: 3.857
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