Literature DB >> 1699800

Monoclonal antibody evidence for structural similarities between the central rod regions of actinin and dystrophin.

T M Nguyen1, J M Ellis, I B Ginjaar, M M van Paassen, G J van Ommen, A F Moorman, A J Cartwright, G E Morris.   

Abstract

A monoclonal antibody, MANDYS141, binds to both dystrophin and actinin on Western blots (SDS-denatured), but only to actinin in frozen sections of human muscle (native conformation). It differs from a polyclonal cross-reacting antiserum in that it binds to several muscle isoforms of actinin (smooth, fast and slow) from man, mouse and chicken and recognises a quite different part of the proposed triple-helical region of dystrophin (amino acids 1750-2248). The results suggest that structural homologies between actinin and dystrophin occur more than once in their central helical regions and provide experimental support for an actinin-like central rod model for dystrophin.

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Year:  1990        PMID： 1699800     DOI： 10.1016/0014-5793(90)80460-z

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Monoclonal antibodies for dystrophin analysis. Epitope mapping and improved binding to SDS-treated muscle sections.

Authors:  T M Nguyen; I B Ginjaar; G J van Ommen; G E Morris
Journal:  Biochem J       Date:  1992-12-01       Impact factor: 3.857

2.  A truncated dystrophin lacking the C-terminal domains is localized at the muscle membrane.

Authors:  T R Helliwell; J M Ellis; R C Mountford; R E Appleton; G E Morris
Journal:  Am J Hum Genet       Date:  1992-03       Impact factor: 11.025

3.  Proceedings of the 2017 National Toxicology Program Satellite Symposium.

Authors:  Susan A Elmore; Famke Aeffner; Dinesh S Bangari; Torrie A Crabbs; Stacey Fossey; Shayne C Gad; Wanda M Haschek; Jessica S Hoane; Kyathanahalli Janardhan; Ramesh C Kovi; Gail Pearse; Lyn M Wancket; Erin M Quist
Journal:  Toxicol Pathol       Date:  2017-11-07       Impact factor: 1.902

4.  Changes in myotonic dystrophy protein kinase levels and muscle development in congenital myotonic dystrophy.

Authors:  Denis Furling; Le Thanh Lam; Onnik Agbulut; Gillian S Butler-Browne; Glenn E Morris
Journal:  Am J Pathol       Date:  2003-03       Impact factor: 4.307

5.  Use of epitope libraries to identify exon-specific monoclonal antibodies for characterization of altered dystrophins in muscular dystrophy.

Authors:  T M Nguyen; G E Morris
Journal:  Am J Hum Genet       Date:  1993-06       Impact factor: 11.025

6.  Localization of the DMDL gene-encoded dystrophin-related protein using a panel of nineteen monoclonal antibodies: presence at neuromuscular junctions, in the sarcolemma of dystrophic skeletal muscle, in vascular and other smooth muscles, and in proliferating brain cell lines.

Authors:  T M Nguyen; J M Ellis; D R Love; K E Davies; K C Gatter; G Dickson; G E Morris
Journal:  J Cell Biol       Date:  1991-12       Impact factor: 10.539

7.  Monoclonal antibodies against the muscle-specific N-terminus of dystrophin: characterization of dystrophin in a muscular dystrophy patient with a frameshift deletion of exons 3-7.

Authors:  T T Le; T M Nguyen; D R Love; T R Helliwell; K E Davies; G E Morris
Journal:  Am J Hum Genet       Date:  1993-07       Impact factor: 11.025

Review 8.  Duchenne and Becker Muscular Dystrophies: A Review of Animal Models, Clinical End Points, and Biomarker Quantification.

Authors:  Kristin Wilson; Crystal Faelan; Janet C Patterson-Kane; Daniel G Rudmann; Steven A Moore; Diane Frank; Jay Charleston; Jon Tinsley; G David Young; Anthony J Milici
Journal:  Toxicol Pathol       Date:  2017-10-03       Impact factor: 1.902

9.  Massive idiosyncratic exon skipping corrects the nonsense mutation in dystrophic mouse muscle and produces functional revertant fibers by clonal expansion.

Authors:  Q L Lu; G E Morris; S D Wilton; T Ly; O V Artem'yeva; P Strong; T A Partridge
Journal:  J Cell Biol       Date:  2000-03-06       Impact factor: 10.539
  9 in total

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