Literature DB >> 16997682

Nonketotic hyperglycemic coma in toddlers after unintentional methadone ingestion.

Sinan Tiras1, Vincent Haas, Laurent Chevret, Marion Decobert, Anne Buisine, Denis Devictor, Philippe Durand, Pierre Tissières.   

Abstract

Methadone overdoses are increasing in parallel with the increased frequency of opiate substitution therapy in adults. Although unintentional methadone intoxication in children is rare, it is becoming more frequently recognized. We report 3 cases of unintentional methadone overdose in toddlers who initially displayed central nervous system depression associated with severe nonketotic hyperglycemia and discuss the possible pathophysiologic mechanisms of an underrecognized symptom of opiate intoxication in young children.

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Year:  2006        PMID: 16997682     DOI: 10.1016/j.annemergmed.2006.02.023

Source DB:  PubMed          Journal:  Ann Emerg Med        ISSN: 0196-0644            Impact factor:   5.721


  6 in total

Review 1.  Endogenous opiates and behavior: 2006.

Authors:  Richard J Bodnar
Journal:  Peptides       Date:  2007-09-11       Impact factor: 3.750

Review 2.  The relationship between opioid and sugar intake: review of evidence and clinical applications.

Authors:  David J Mysels; Maria A Sullivan
Journal:  J Opioid Manag       Date:  2010 Nov-Dec

3.  Methadone toxicity and possible induction and enhanced elimination in a premature neonate.

Authors:  Mathew George; Joseph P Kitzmiller; Michele Burns Ewald; Katherine A O'Donell; Melissa Lai Becter; Steve Salhanick
Journal:  J Med Toxicol       Date:  2012-12

4.  Methadone-induced hypoglycemia.

Authors:  Andrew J Faskowitz; Vladimir N Kramskiy; Gavril W Pasternak
Journal:  Cell Mol Neurobiol       Date:  2013-03-07       Impact factor: 5.046

5.  Effectiveness of naltrexone in the prevention of delayed respiratory arrest in opioid-naive methadone-intoxicated patients.

Authors:  Abbas Aghabiklooei; Hossein Hassanian-Moghaddam; Nasim Zamani; Shahin Shadnia; Mohammad Mashayekhian; Mitra Rahimi; Soheil Nasouhi; Ahmad Ghoochani
Journal:  Biomed Res Int       Date:  2013-09-09       Impact factor: 3.411

6.  Are empty methadone bottles empty? An analytic study.

Authors:  Gaël Dupuy; Lia Cavalcanti; Emmanuel Bourgogne; Clara Brichant-Petitjean; Léon Gomberoff; Vanessa Bloch; Frank Bellivier; Jean-Pierre Lépine; Olivier Laprévote; Florence Vorspan
Journal:  Harm Reduct J       Date:  2014-07-02
  6 in total

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