| Literature DB >> 16997559 |
Paul Bamborough1, John A Christopher, Geoffrey J Cutler, Marion C Dickson, Geoffrey W Mellor, James V Morey, Champa B Patel, Lisa M Shewchuk.
Abstract
The identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-epsilon kinase is described. Compound 12e was identified with an IKK-epsilon enzyme potency of pIC(50) 7.4, and has a highly encouraging wider selectivity profile, including selectivity within the IKK kinase family.Entities:
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Year: 2006 PMID： 16997559 DOI： 10.1016/j.bmcl.2006.09.018
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823