| Literature DB >> 16997557 |
Nobuto Minowa1, Yoshihisa Akiyama, Yukiko Hiraiwa, Kazunori Maebashi, Takayuki Usui, Daishiro Ikeda.
Abstract
Synthesis and activity of derivatives at the O5 or O6 positions of 1-N-((S)-4-amino-2-hydroxybutyryl)-3',4'-dideoxyneamine, which is the neamine moiety of arbekacin, were reported. Among these results, the 5-O-aminoethylaminocarbonyl derivative showed effective activity against Staphylococcus aureus expressing a bifunctional aminoglycoside-modifying enzyme AAC(6')-APH(2'').Entities:
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Year: 2006 PMID： 16997557 DOI： 10.1016/j.bmcl.2006.09.007
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823