| Literature DB >> 16997556 |
Mark Sabat1, John C VanRens, Matthew J Laufersweiler, Todd A Brugel, Jennifer Maier, Adam Golebiowski, Biswanath De, Vijayasurian Easwaran, Lily C Hsieh, Richard L Walter, Marlene J Mekel, Artem Evdokimov, Michael J Janusz.
Abstract
This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed low nanomolar activity for the inhibition of Lck kinase and a representative analog was co-crystallized with Hck (a structurally related member of the Src family kinases).Entities:
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Year: 2006 PMID： 16997556 DOI： 10.1016/j.bmcl.2006.08.132
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823