Literature DB >> 1699633

Cell membrane changes in brains manifesting senile plaques: an immunohistochemical study of GM1 membranous ganglioside.

N Iwamoto1, Y Suzuki, Y Makino, C Haga, K Kosaka, R Iizuka.   

Abstract

To investigate structural changes in cell membranes of the Alzheimer-type dementia (ATD) brain, we immunostained for GM1 ganglioside which is a major component of the cell membrane. Our results have shown that astrocytic membranes and senile plaques (SPs) have the same immunoreactivity against the monoclonal anti-ganglioside GM1 antibody. Moreover, the astrocytic processes within the SPs were altered and their abnormal membranes seemed to contribute to the formation of SPs.

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Year:  1990        PMID： 1699633     DOI： 10.1016/0006-8993(90)91592-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  6 in total

1.  Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

Authors:  M A Pappolla; R A Omar; K S Kim; N K Robakis
Journal:  Am J Pathol       Date:  1992-03       Impact factor: 4.307

Review 2.  Siglec receptors and hiding plaques in Alzheimer's disease.

Authors:  Antero Salminen; Kai Kaarniranta
Journal:  J Mol Med (Berl)       Date:  2009-04-24       Impact factor: 4.599

3.  The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice.

Authors:  Kay N Greenshields; Susan K Halstead; Femke M P Zitman; Simon Rinaldi; Kathryn M Brennan; Colin O'Leary; Luke H Chamberlain; Alistair Easton; Jennifer Roxburgh; John Pediani; Koichi Furukawa; Keiko Furukawa; Carl S Goodyear; Jaap J Plomp; Hugh J Willison
Journal:  J Clin Invest       Date:  2009-02-16       Impact factor: 14.808

4.  The pathological roles of ganglioside metabolism in Alzheimer's disease: effects of gangliosides on neurogenesis.

Authors:  Toshio Ariga; Chandramohan Wakade; Robert K Yu
Journal:  Int J Alzheimers Dis       Date:  2011-01-09

Review 5.  Gangliosides as Biomarkers of Human Brain Diseases: Trends in Discovery and Characterization by High-Performance Mass Spectrometry.

Authors:  Mirela Sarbu; Raluca Ica; Alina D Zamfir
Journal:  Int J Mol Sci       Date:  2022-01-08       Impact factor: 5.923

6.  Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease.

Authors:  Lucía Viejo; Ayush Noori; Emily Merrill; Sudeshna Das; Bradley T Hyman; Alberto Serrano-Pozo
Journal:  Neuropathol Appl Neurobiol       Date:  2021-08-17       Impact factor: 6.250
  6 in total

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