Literature DB >> 1699569

The effect of subunit composition of rat brain GABAA receptors on channel function.

E Sigel1, R Baur, G Trube, H Möhler, P Malherbe.   

Abstract

Different combinations of cloned rat brain subunit isoforms of the GABAA receptor channel were expressed in Xenopus oocytes. The voltage-clamp technique was then used to measure properties of the GABA-induced membrane currents and to study the effects of various modulators of the GABAA receptor channel (diazepam, DMCM, pentobarbital, and picrotoxin). This approach was used to obtain information on the minimal structural requirements for several functional properties of the ion channel. The combination alpha 5 beta 2 gamma 2 was identified as the minimal requirement reproducing consensus properties of the vertebrate GABAA receptor channel, including cooperativity of GABA-dependent channel gating with a Ka in the range of 10 microM, modulation by various drugs acting at the benzodiazepine binding site, picrotoxin sensitivity, and barbiturate effects.

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Year:  1990        PMID： 1699569     DOI： 10.1016/0896-6273(90)90224-4

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  122 in total

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Authors:  M D Krasowski; N L Harrison
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2.  Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression.

Authors:  P M Taylor; P Thomas; G H Gorrie; C N Connolly; T G Smart; S J Moss
Journal:  J Neurosci       Date:  1999-08-01       Impact factor: 6.167

3.  Dual mode of stimulation by the beta-carboline ZK 91085 of recombinant GABA(A) receptor currents: molecular determinants affecting its action.

Authors:  U Thomet; R Baur; P Scholze; W Sieghart; E Sigel
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4.  Response kinetics and pharmacological properties of heteromeric receptors formed by coassembly of GABA rho- and gamma 2-subunits.

Authors:  H Qian; H Ripps
Journal:  Proc Biol Sci       Date:  1999-12-07       Impact factor: 5.349

5.  Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine.

Authors:  Y Chang; D S Weiss
Journal:  Biophys J       Date:  1999-11       Impact factor: 4.033

6.  Proton sensitivity of rat cerebellar granule cell GABAA receptors: dependence on neuronal development.

Authors:  B J Krishek; T G Smart
Journal:  J Physiol       Date:  2001-01-15       Impact factor: 5.182

7.  The expression of GABA(A) receptor subunits in the substantia nigra is developmentally regulated and region-specific.

Authors:  J Velísková; H Kubová; L K Friedman; R Wu; E F Sperber; R S Zukin; S L Moshé
Journal:  Ital J Neurol Sci       Date:  1998-08

8.  Single-channel properties of neuronal GABAA receptors from mice lacking the 2 subunit.

Authors:  M Lorez; D Benke; B Luscher; H Mohler; J A Benson
Journal:  J Physiol       Date:  2000-08-15       Impact factor: 5.182

9.  An initiator element mediates autologous downregulation of the human type A gamma -aminobutyric acid receptor beta 1 subunit gene.

Authors:  S J Russek; S Bandyopadhyay; D H Farb
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-18       Impact factor: 11.205

10.  GABA-induced current and circadian regulation of chloride in neurones of the rat suprachiasmatic nucleus.

Authors:  S Wagner; N Sagiv; Y Yarom
Journal:  J Physiol       Date:  2001-12-15       Impact factor: 5.182
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