Effects of salt loading and haemodilution on the responses of perfused cat kidneys to angiotensin.

1. Effects of single intra-arterial injections (0.1-1.0 mug) of angiotensin II have been observed on cat kidneys perfused with heparinized blood from heart-lung circuits.2. Angiotensin II always caused an abrupt decrease in renal plasma flow (R.P.F.) which reached maximum in 1-2 min and lasted over-all for only 3.5-4.0 min. Glomerular filtration rate (G.F.R.) usually and filtration fraction (F.F.) always increased.3. Angiotensin II caused antidiuresis provided that the kidney had not been subjected either to salt loading or to haemodilution within the preceding 3 hr. These pretreatments converted the antidiuretic action of angiotensin into a diuresis.4. Angiotensin II raised the rate of Na excretion, the urinary concentration of Na and the urinary Na/K whether anti-diuretic or diuretic.