The experimental induction of hypophosphataemia in goats using anion exchange columns.

1. Inorganic phosphate was selectively removed from the circulating blood of five anaesthetized goats by means of columns of anion-exchange resin. Concentrations of other ions were unaffected by the column.2. Rates of inorganic phosphate extraction in excess of 5 m-moles/hr caused a fall in plasma inorganic phosphate of up to 50% in 30 min.3. In four of the goats the calculated inorganic phosphate mobilization rate rose sharply to a maximum between 5.8 and 12.7 m-moles/hr and then fell progressively as more phosphate was removed.4. During the course of the experiments a fall in blood pressure occurred, accompanied by a rise in blood glucose. The reasons for this are discussed.