Literature DB >> 16991078

Cross-protectiveness and immunogenicity of influenza A/Duck/Singapore/3/97(H5) vaccines against infection with A/Vietnam/1203/04(H5N1) virus in ferrets.

Aleksandr S Lipatov1, Erich Hoffmann, Rachelle Salomon, Hui-Ling Yen, Robert G Webster.   

Abstract

Ferrets were immunized with two 7- mu g doses of hemagglutinin from inactivated whole-virus vaccines containing the hemagglutinin gene of A/Duck/Singapore/3/97(H5N3) then inoculated with a lethal dose of A/Vietnam/1203/04(H5N1) (Viet/1203/04). Serum samples did not react with Viet/1203/04 in hemagglutination-inhibition (HI) or virus-neutralization (VN) tests. All vaccinated ferrets survived the challenge, whereas all mock-immunized ferrets died. Immunized ferrets had significantly lower virus titers in the upper respiratory tract and less-severe disease. Vaccine generated from antigenically different H5 virus protects against infection by a highly pathogenic H5 strain. Neither HI nor VN testing provides correlates of cross-protection in ferrets.

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Year:  2006        PMID： 16991078     DOI： 10.1086/507709

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  45 in total

1.  Protective immunity against H5N1 influenza virus by a single dose vaccination with virus-like particles.

Authors:  Jae-Min Song; Jaber Hossain; Dae-Goon Yoo; Aleksandr S Lipatov; C Todd Davis; Fu-Shi Quan; Li-Mei Chen; Robert J Hogan; Ruben O Donis; Richard W Compans; Sang-Moo Kang
Journal:  Virology       Date:  2010-06-26       Impact factor: 3.616

Review 2.  The threat of avian influenza A (H5N1). Part IV: Development of vaccines.

Authors:  Jindrich Cinatl; Martin Michaelis; Hans W Doerr
Journal:  Med Microbiol Immunol       Date:  2007-06-01       Impact factor: 3.402

3.  The generation of influenza outbreaks by a network of host immune responses against a limited set of antigenic types.

Authors:  Mario Recker; Oliver G Pybus; Sean Nee; Sunetra Gupta
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-25       Impact factor: 11.205

4.  A computationally optimized hemagglutinin virus-like particle vaccine elicits broadly reactive antibodies that protect nonhuman primates from H5N1 infection.

Authors:  Brendan M Giles; Corey J Crevar; Donald M Carter; Stephanie J Bissel; Stacey Schultz-Cherry; Clayton A Wiley; Ted M Ross
Journal:  J Infect Dis       Date:  2012-03-23       Impact factor: 5.226

5.  Immunization of primates with a Newcastle disease virus-vectored vaccine via the respiratory tract induces a high titer of serum neutralizing antibodies against highly pathogenic avian influenza virus.

Authors:  Joshua M DiNapoli; Lijuan Yang; Amorsolo Suguitan; Subbiah Elankumaran; David W Dorward; Brian R Murphy; Siba K Samal; Peter L Collins; Alexander Bukreyev
Journal:  J Virol       Date:  2007-08-22       Impact factor: 5.103

Review 6.  Influenza vaccines.

Authors:  A H Ellebedy; R J Webby
Journal:  Vaccine       Date:  2009-11-05       Impact factor: 3.641

7.  Recombinant parainfluenza virus 5 vaccine encoding the influenza virus hemagglutinin protects against H5N1 highly pathogenic avian influenza virus infection following intranasal or intramuscular vaccination of BALB/c mice.

Authors:  Alaina J Mooney; Zhuo Li; Jon D Gabbard; Biao He; S Mark Tompkins
Journal:  J Virol       Date:  2012-10-17       Impact factor: 5.103

8.  A pilot study of the immune response to whole inactivated avian influenza H7N1 virus vaccine in mice.

Authors:  Arnt-Ove Hovden; Karl A Brokstad; Diane Major; John Wood; Lars R Haaheim; Rebecca J Cox
Journal:  Influenza Other Respir Viruses       Date:  2009-01       Impact factor: 4.380

9.  Multivalent HA DNA vaccination protects against highly pathogenic H5N1 avian influenza infection in chickens and mice.

Authors:  Srinivas Rao; Wing-Pui Kong; Chih-Jen Wei; Zhi-Yong Yang; Martha Nason; Darrel Styles; Louis J DeTolla; Aruna Panda; Erin M Sorrell; Haichen Song; Hongquan Wan; Gloria C Ramirez-Nieto; Daniel Perez; Gary J Nabel
Journal:  PLoS One       Date:  2008-06-18       Impact factor: 3.240

10.  Confronting potential influenza A (H5N1) pandemic with better vaccines.

Authors:  Azizul Haque; Didier Hober; Lloyd H Kasper
Journal:  Emerg Infect Dis       Date:  2007-10       Impact factor: 6.883
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