Literature DB >> 1699101

Perforin-mediated myocardial damage in acute myocarditis.

L H Young1, S V Joag, L M Zheng, C P Lee, Y S Lee, J D Young.   

Abstract

Endomyocardial specimens were obtained from 7 patients with acute myocarditis. Immunohistochemical examination of the mononuclear infiltrate showed mainly cytotoxic T lymphocytes and natural killer cells. Perforin (a pore-forming protein found in cytotoxic lymphocytes) was identified in this myocardial lymphocytic infiltrate and electron microscopy showed myocardial cell damage that may have been associated with these perforin containing lymphocytes. The results indicate that in acute idiopathic and viral myocarditis, myocardial damage may be due to the action of perforin-secreting lymphocytes.

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Year:  1990        PMID： 1699101     DOI： 10.1016/0140-6736(90)92486-2

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  22 in total

Review 1.  Perforin and its role in T lymphocyte-mediated cytolysis.

Authors:  B Lowin; O Krähenbühl; C Müller; M Dupuis; J Tschopp
Journal:  Experientia       Date:  1992-10-15

2.  Perforin activity at membranes leads to invaginations and vesicle formation.

Authors:  Tilen Praper; Andreas F-P Sonnen; Ales Kladnik; Alberto O Andrighetti; Gabriella Viero; Keith J Morris; Emanuela Volpi; Lorenzo Lunelli; Mauro Dalla Serra; Christopher J Froelich; Robert J C Gilbert; Gregor Anderluh
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-15       Impact factor: 11.205

3.  Cytolytic and ion channel-forming properties of the N terminus of lymphocyte perforin.

Authors:  D M Ojcius; P M Persechini; L M Zheng; P C Notaroberto; S C Adeodato; J D Young
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

Review 4.  Effects of MACPF/CDC proteins on lipid membranes.

Authors:  Robert J C Gilbert; Miha Mikelj; Mauro Dalla Serra; Christopher J Froelich; Gregor Anderluh
Journal:  Cell Mol Life Sci       Date:  2012-09-15       Impact factor: 9.261

5.  Expression of cytolytic mediators by synovial fluid lymphocytes in rheumatoid arthritis.

Authors:  L H Young; S V Joag; P Y Lin; S F Luo; L M Zheng; C C Liu; J D Young
Journal:  Am J Pathol       Date:  1992-05       Impact factor: 4.307

6.  Fulminant myocarditis demonstrating uncommon morphology--a report of two autopsy cases.

Authors:  Kuniyuki Oka; Koji Oohira; Yasushi Yatabe; Toshio Tanaka; Kozo Kurano; Rie Kosugi; Minoru Murata; Hando Hakozaki; Toshio Nishikawa; Yutaka Tsutsumi
Journal:  Virchows Arch       Date:  2005-01-25       Impact factor: 4.064

7.  Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis.

Authors:  N Goebels; D Michaelis; M Engelhardt; S Huber; A Bender; D Pongratz; M A Johnson; H Wekerle; J Tschopp; D Jenne; R Hohlfeld
Journal:  J Clin Invest       Date:  1996-06-15       Impact factor: 14.808

Review 8.  Viral myocarditis and dilated cardiomyopathy: mechanisms, manifestations, and management.

Authors:  M T Kearney; J M Cotton; P J Richardson; A M Shah
Journal:  Postgrad Med J       Date:  2001-01       Impact factor: 2.401

9.  Perforin expression by thyroid-infiltrating T cells in autoimmune thyroid disease.

Authors:  Z Wu; E R Podack; J M McKenzie; K J Olsen; M Zakarija
Journal:  Clin Exp Immunol       Date:  1994-12       Impact factor: 4.330

10.  Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody.

Authors:  A Hameed; K J Olsen; L Cheng; W M Fox; R H Hruban; E R Podack
Journal:  Am J Pathol       Date:  1992-05       Impact factor: 4.307
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