Literature DB >> 16991001

Sequence and function of canine herpesvirus alpha-transinducing factor and its interaction with an immediate early promoter.

Scott G Tyack1, Michael J Studdert, Michael A Johnson.   

Abstract

The sequence of the alpha-transinducing factor (alpha-TIF) of canine herpesvirus (CHV-l) was determined. Alignment of the predicted CHV-1 alpha-TIF amino acid sequence with other alpha-TIF homologues reveals a core region of similarity with divergent amino and carboxyl termini. Analysis of the CHV-1 infected cell protein 4 promoter region identified a region containing nine copies of a 52 bp repeat that showed significant up-regulation of transcription by alpha-TIF. This region contained an imperfect 'TAATGARAT' motif, the binding site for herpes simplex virus 1 alpha-TIF, with an imperfect Oct-1 binding site immediately following. The infectious laryngotracheitis virus alpha-TIF was also shown to up-regulate transcription through this region of the promoter. Transfection of CHV-1 genomic DNA failed to yield infectious virus in canine kidney cell lines. Co-transfection of genomic DNA and an alpha-TIF expression plasmid resulted in virus plaques, indicating a potential essential role for alpha-TIF in CHV-1 infection.

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Year:  2006        PMID： 16991001     DOI： 10.1007/s11262-006-0069-5

Source DB:  PubMed          Journal:  Virus Genes        ISSN： 0920-8569            Impact factor:   2.332


  62 in total

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Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

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Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

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Authors:  Masahiro Miyoshi; Katsunori Okazaki; Mitsuyoshi Takiguchi; Hiroshi Kida; Akira Hashimoto
Journal:  J Vet Med Sci       Date:  2002-07       Impact factor: 1.267
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  2 in total

1.  Duck Plague Virus pUL48 Protein Activates the Immediate-Early Gene to Initiate the Transcription of the Virus Gene.

Authors:  Tong Zhou; Dengjian Fan; Mingshu Wang; Anchun Cheng; Ying Wu; Qiao Yang; Bin Tian; Renyong Jia; Xumin Ou; Sai Mao; Di Sun; Shaqiu Zhang; Dekang Zhu; Shun Chen; Mafeng Liu; Xin-Xin Zhao; Juan Huang; Qun Gao; Yanling Yu; Ling Zhang
Journal:  Front Microbiol       Date:  2021-12-23       Impact factor: 5.640

2.  Genome Sequence of Canine Herpesvirus.

Authors:  Konstantinos V Papageorgiou; Nicolás M Suárez; Gavin S Wilkie; Michael McDonald; Elizabeth M Graham; Andrew J Davison
Journal:  PLoS One       Date:  2016-05-23       Impact factor: 3.240
  2 in total

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