Literature DB >> 16990929

Rapamycin biosynthesis: Elucidation of gene product function.

Matthew A Gregory1, Hui Hong, Rachel E Lill, Sabine Gaisser, Hrvoje Petkovic, Lindsey Low, Lesley S Sheehan, Isabelle Carletti, Sarah J Ready, Michael J Ward, Andrew L Kaja, Alison J Weston, Iain R Challis, Peter F Leadlay, Christine J Martin, Barrie Wilkinson, Rose M Sheridan.   

Abstract

The function of gene products involved in the biosynthesis of the clinically important polyketide rapamycin were elucidated by biotransformation and gene complementation.

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Year:  2006        PMID： 16990929     DOI： 10.1039/b608813a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  15 in total

Review 1.  Streptomyces temperate bacteriophage integration systems for stable genetic engineering of actinomycetes (and other organisms).

Authors:  Richard H Baltz
Journal:  J Ind Microbiol Biotechnol       Date:  2011-12-13       Impact factor: 3.346

2.  FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation.

Authors:  Dandan Chen; Lihan Zhang; Bo Pang; Jing Chen; Zhinan Xu; Ikuro Abe; Wen Liu
Journal:  J Bacteriol       Date:  2013-02-22       Impact factor: 3.490

Review 3.  Caloric restriction and chronic inflammatory diseases.

Authors:  O A González; C Tobia; J L Ebersole; M J Novak
Journal:  Oral Dis       Date:  2011-07-13       Impact factor: 3.511

4.  Characterization of negative regulatory genes for the biosynthesis of rapamycin in Streptomyces rapamycinicus and its application for improved production.

Authors:  Young Ji Yoo; Jae-Yeon Hwang; Hea-Luyung Shin; Heqing Cui; Jinwon Lee; Yeo Joon Yoon
Journal:  J Ind Microbiol Biotechnol       Date:  2014-11-26       Impact factor: 3.346

5.  Origin of the allyl group in FK506 biosynthesis.

Authors:  Dusan Goranovic; Gregor Kosec; Peter Mrak; Stefan Fujs; Jaka Horvat; Enej Kuscer; Gregor Kopitar; Hrvoje Petkovic
Journal:  J Biol Chem       Date:  2010-03-01       Impact factor: 5.157

6.  Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.

Authors:  Jennifer N Andexer; Steven G Kendrew; Mohammad Nur-e-Alam; Orestis Lazos; Teresa A Foster; Anna-Sophie Zimmermann; Tony D Warneck; Dipen Suthar; Nigel J Coates; Frank E Koehn; Jerauld S Skotnicki; Guy T Carter; Matthew A Gregory; Christine J Martin; Steven J Moss; Peter F Leadlay; Barrie Wilkinson
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-07       Impact factor: 11.205

Review 7.  An overview of rapamycin: from discovery to future perspectives.

Authors:  Young Ji Yoo; Hanseong Kim; Sung Ryeol Park; Yeo Joon Yoon
Journal:  J Ind Microbiol Biotechnol       Date:  2016-09-09       Impact factor: 3.346

8.  Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.

Authors:  Enej Kuscer; Nigel Coates; Iain Challis; Matt Gregory; Barrie Wilkinson; Rose Sheridan; Hrvoje Petković
Journal:  J Bacteriol       Date:  2007-04-27       Impact factor: 3.490

9.  An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35.

Authors:  Tina Netzker; Volker Schroeckh; Matthew A Gregory; Michal Flak; Mario K C Krespach; Peter F Leadlay; Axel A Brakhage
Journal:  Appl Environ Microbiol       Date:  2016-05-31       Impact factor: 4.792

10.  Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase.

Authors:  Kei Kudo; Takehiro Nishimura; Ikuko Kozone; Junko Hashimoto; Noritaka Kagaya; Hikaru Suenaga; Haruo Ikeda; Kazuo Shin-Ya
Journal:  Sci Rep       Date:  2021-05-11       Impact factor: 4.379
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