Literature DB >> 16990004

Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase.

Yili Ding1, Kenneth L Smith, Chamakura V N S Varaprasad, Eugene Chang, John Alexander, Nanhua Yao.   

Abstract

Several thiazolone-based sulfonamides were prepared, utilizing various hetero-aryl sulfonyl chlorides and different aldehydes, as inhibitors of NS5B polymerase, to target HCV. The best compound showed 0.6 microM [corrected] of IC50 inhibitory activity.

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Year:  2006        PMID： 16990004     DOI： 10.1016/j.bmcl.2006.08.104

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

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Authors:  Robert G Batey
Journal:  World J Gastroenterol       Date:  2007-08-21       Impact factor: 5.742

2.  Combination of pharmacophore hypothesis and molecular docking to identify novel inhibitors of HCV NS5B polymerase.

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3.  Discovery of potent Covid-19 main protease inhibitors using integrated drug-repurposing strategy.

Authors:  Muthu Kumar T; Rohini K; Nivya James; Shanthi V; Ramanathan K
Journal:  Biotechnol Appl Biochem       Date:  2021-04-14       Impact factor: 2.724

Review 4.  5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry.

Authors:  Danylo Kaminskyy; Anna Kryshchyshyn; Roman Lesyk
Journal:  Eur J Med Chem       Date:  2017-09-20       Impact factor: 6.514

Review 5.  Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids.

Authors:  Dmytro Havrylyuk; Olexandra Roman; Roman Lesyk
Journal:  Eur J Med Chem       Date:  2016-02-16       Impact factor: 6.514

6.  Efficient Synthesis and Docking Studies of Novel Benzothiazole-Based Pyrimidinesulfonamide Scaffolds as New Antiviral Agents and Hsp90α Inhibitors.

Authors:  Rasha A Azzam; Rokia R Osman; Galal H Elgemeie
Journal:  ACS Omega       Date:  2020-01-09

7.  2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase.

Authors:  Ilkay Küçükgüzel; Gökhan Satılmış; K R Gurukumar; Amartya Basu; Esra Tatar; Daniel B Nichols; Tanaji T Talele; Neerja Kaushik-Basu
Journal:  Eur J Med Chem       Date:  2013-09-12       Impact factor: 6.514

8.  Concerted solvent processes for common sulfonyl chloride precursors used in the synthesis of sulfonamide-based drugs.

Authors:  Malcolm J D'Souza; Lamia Yaakoubd; Stacey L Mlynarski; Dennis N Kevill
Journal:  Int J Mol Sci       Date:  2008-05-24       Impact factor: 6.208

9.  Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of thiazolone derivatives as hepatitis C virus NS5B polymerase allosteric inhibitors.

Authors:  Beilei Lei; Juan Du; Shuyan Li; Huanxiang Liu; Yueying Ren; Xiaojun Yao
Journal:  J Comput Aided Mol Des       Date:  2008-08-21       Impact factor: 3.686
  9 in total

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