Literature DB >> 16989915

Beneficial effects of FK506 for experimental temporal lobe epilepsy.

Tsutomu Nishimura1, Hideki Imai, Yoshio Minabe, Akira Sawa, Nobumasa Kato.   

Abstract

FK506, originally classified as an immunosuppressant, may also be implicated in some events in the central nervous system. FK506 elicits both neuroprotective and neurotrophic effects in vitro. FK506 is neuroprotective for focal cerebral ischemia, but it is not clear whether FK506 has neuroprotective effects for other brain diseases. In this study, we investigated possible neuroprotective effects of FK506 in experimental temporal lobe epilepsy (TLE) induced by kainic acid (KA) or trimethyltin (TMT). In rat models, we observed marked protection against seizures, abnormal behaviors, and accompanying delayed neuronal damage in the hippocampus by the systemic injection of FK506.

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Year:  2006        PMID： 16989915     DOI： 10.1016/j.neures.2006.08.006

Source DB:  PubMed          Journal:  Neurosci Res        ISSN： 0168-0102            Impact factor:   3.304


  6 in total

1.  Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction.

Authors:  Yuetao Wen; Pengfei Fu; Kunlun Wu; Kaichuang Si; Yanfeng Xie; Wei Dan; Yan Zhan; Quanhong Shi
Journal:  Neurochem Res       Date:  2017-03-15       Impact factor: 3.996

2.  Role of autophagy inhibitors and inducers in modulating the toxicity of trimethyltin in neuronal cell cultures.

Authors:  C Fabrizi; F Somma; E Pompili; F Biagioni; P Lenzi; F Fornai; L Fumagalli
Journal:  J Neural Transm (Vienna)       Date:  2012-03-14       Impact factor: 3.575

Review 3.  Neuroprotective strategies in hippocampal neurodegeneration induced by the neurotoxicant trimethyltin.

Authors:  V Corvino; E Marchese; F Michetti; M C Geloso
Journal:  Neurochem Res       Date:  2012-11-25       Impact factor: 3.996

4.  Rutin supplementation in the diet has protective effects against toxicant-induced hippocampal injury by suppression of microglial activation and pro-inflammatory cytokines: protective effect of rutin against toxicant-induced hippocampal injury.

Authors:  Tomoko Koda; Yoshiki Kuroda; Hideki Imai
Journal:  Cell Mol Neurobiol       Date:  2009-01-21       Impact factor: 5.046

5.  Status Epilepticus Triggers Time-Dependent Alterations in Microglia Abundance and Morphological Phenotypes in the Hippocampus.

Authors:  Season K Wyatt-Johnson; Seth A Herr; Amy L Brewster
Journal:  Front Neurol       Date:  2017-12-18       Impact factor: 4.003

6.  Neuroprotective Effect of Protaetia brevitarsis seulensis' Water Extract on Trimethyltin-Induced Seizures and Hippocampal Neurodegeneration.

Authors:  Sueun Lee; Young Hye Seo; Jun Ho Song; Wook Jin Kim; Ji Hye Lee; Byeong Cheol Moon; Mary Jasmin Ang; Sung Ho Kim; Changjong Moon; Jun Lee; Joong Sun Kim
Journal:  Int J Mol Sci       Date:  2021-01-12       Impact factor: 5.923
  6 in total

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