Literature DB >> 16989612

HIV type 1 zidovudine (ZDV) resistance in blood and uterine cervical secretions of pregnant women.

Lisa M Frenkel1, Jennifer McKernan, Phil V Dinh, Deborah Goldman, Jane Hitti, D Heather Watts, Ellen R Cooper, Joan Dragavon, Robert W Coombs.   

Abstract

To determine if HIV-1 resistance testing of the blood predicts mutants in the genital secretions of ZDV-treated pregnant women, ZDV resistance mutations were assessed by an oligonucleotide ligation assay. ZDV resistance was detected in viral sequences from blood (16/48; 33%) and cervical secretions (6/24; 25%) collected during 57 pregnancies. The genotype of 11/69 (16%) resistance codons was discordant between blood and cervical virus of pregnant women near term. However, in only 1 (1.8%) of 57 pregnancies evaluated was resistant virus limited to the cervical secretions. ZDV-resistant virus is rarely limited to the female genital tract.

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Year:  2006        PMID： 16989612     DOI： 10.1089/aid.2006.22.870

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  4 in total

1.  Antiretroviral treatment interruptions predict female genital shedding of genotypically resistant HIV-1 RNA.

Authors:  Susan M Graham; Zahra Jalalian-Lechak; Juma Shafi; Vrasha Chohan; Ruth W Deya; Walter Jaoko; Kishor N Mandaliya; Norbert M Peshu; Julie Overbaugh; R Scott McClelland
Journal:  J Acquir Immune Defic Syndr       Date:  2012-08-15       Impact factor: 3.731

2.  Resistance detected by pyrosequencing following zidovudine monotherapy for prevention of HIV-1 mother-to-child-transmission.

Authors:  Scott C Olson; Nicole Ngo-Giang-Huong; Ingrid Beck; Wenjie Deng; Paula Britto; David E Shapiro; Roger E Bumgarner; James I Mullins; Russell B Van Dyke; Gonzague Jourdain; Lisa M Frenkel
Journal:  AIDS       Date:  2015-07-31       Impact factor: 4.177

3.  Compartmentalization of HIV-1 within the female genital tract is due to monotypic and low-diversity variants not distinct viral populations.

Authors:  Marta Bull; Gerald Learn; Indira Genowati; Jennifer McKernan; Jane Hitti; David Lockhart; Kenneth Tapia; Sarah Holte; Joan Dragavon; Robert Coombs; James Mullins; Lisa Frenkel
Journal:  PLoS One       Date:  2009-09-22       Impact factor: 3.240

4.  HIV-1 RNA levels and antiretroviral drug resistance in blood and non-blood compartments from HIV-1-infected men and women enrolled in AIDS clinical trials group study A5077.

Authors:  Rami Kantor; Daniel Bettendorf; Ronald J Bosch; Marita Mann; David Katzenstein; Susan Cu-Uvin; Richard D'Aquila; Lisa Frenkel; Susan Fiscus; Robert Coombs
Journal:  PLoS One       Date:  2014-04-03       Impact factor: 3.240
  4 in total

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