Literature DB >> 16989532

Alkaloids from Gelsemium elegans.

You-Kai Xu1, Sheng-Ping Yang, Shang-Gao Liao, Hua Zhang, Li-Ping Lin, Jian Ding, Jian-Min Yue.   

Abstract

Three new alkaloids, gelsebanine (1), 14alpha-hydroxyelegansamine (2), and 14alpha-hydroxygelsamydine (3), and a new extraction artifact , gelsebamine (4), together with 12 known alkaloids, were isolated from the stems and leaves of Gelsemium elegans. The structures of 1-4 were determined by spectroscopic methods, especially 2D NMR techniques. Compounds 1-4 were evaluated for cytotoxic activity against four tumor cell lines, and gelsebamine (4) selectively inhibited the A-549 human lung adenocarcinoma cell line.

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Year:  2006        PMID： 16989532     DOI： 10.1021/np060156y

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

1.  Asymmetric synthesis of allenyl oxindoles and spirooxindoles by a catalytic enantioselective Saucy-Marbet Claisen rearrangement.

Authors:  Trung Cao; Joshua Deitch; Elizabeth C Linton; Marisa C Kozlowski
Journal:  Angew Chem Int Ed Engl       Date:  2012-01-27       Impact factor: 15.336

2.  Copper(II)- and palladium(II)-catalyzed enantioselective Claisen rearrangement of allyloxy- and propargyloxy-indoles to quaternary oxindoles and spirocyclic lactones.

Authors:  Trung Cao; Elizabeth C Linton; Joshua Deitch; Simon Berritt; Marisa C Kozlowski
Journal:  J Org Chem       Date:  2012-12-04       Impact factor: 4.354

Review 3.  Discovery of structurally diverse and bioactive compounds from plant resources in China.

Authors:  Sheng-Ping Yang; Jian-Min Yue
Journal:  Acta Pharmacol Sin       Date:  2012-09-03       Impact factor: 6.150

4.  Alkaloids extracted from Pterogyne nitens induce apoptosis in malignant breast cell line.

Authors:  Roberta Aparecida Duarte; Elaine Rodrigues Mello; Camila Araki; Vanderlan da Silva Bolzani; Dulce Helena Siqueira e Silva; Luis Octavio Regasini; Tarsia Giabardo Alves Silva; Mauro César Cafundó de Morais; Valdecir Farias Ximenes; Christiane Pienna Soares
Journal:  Tumour Biol       Date:  2010-08-11

5.  The genus Gelsemium: An update.

Authors:  V Dutt; S Thakur; V J Dhar; A Sharma
Journal:  Pharmacogn Rev       Date:  2010-07

Review 6.  Spirocyclic Motifs in Natural Products.

Authors:  Evgeny Chupakhin; Olga Babich; Alexander Prosekov; Lyudmila Asyakina; Mikhail Krasavin
Journal:  Molecules       Date:  2019-11-17       Impact factor: 4.411

7.  Tin(iv) chloride mediated (3 + 2) annulation of trans-2-aroyl-3-styrylcyclopropane-1,1-dicarboxylates with nitriles: diastereoselective access to 5-vinyl-1-pyrroline derivatives.

Authors:  Murugesan Thangamani; Subaramaniam Thangamalar; Kannupal Srinivasan
Journal:  RSC Adv       Date:  2021-04-21       Impact factor: 3.361

Review 8.  Gelsemium elegans Benth: Chemical Components, Pharmacological Effects, and Toxicity Mechanisms.

Authors:  Hailing Lin; Hongqiang Qiu; Yu Cheng; Maobai Liu; Maohua Chen; Youxiong Que; Wancai Que
Journal:  Molecules       Date:  2021-11-25       Impact factor: 4.411

9.  The metabolism of gelsevirine in human, pig, goat and rat liver microsomes.

Authors:  Hua-Hai Zhang; Wen-Jia Yang; Ya-Jun Huang; Wen-Jing Li; Shuo-Xin Zhang; Zhao-Ying Liu
Journal:  Vet Med Sci       Date:  2021-05-06
  9 in total

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