Literature DB >> 16988524

APOBEC3G genetic variants and their association with risk of HIV infection in highly exposed Caucasians.

Han Sang Valcke1, Nicole F Bernard, Julie Bruneau, Michel Alary, Christos M Tsoukas, Michel Roger.   

Abstract

The cytosine deaminase APOBEC3G has been identified as a host factor that inhibits HIV-1 replication. We investigated whether genetic variants of APOBEC3G that could potentially affect the protein's expression or function were associated with the risk of infection in 122 Caucasians highly exposed to HIV-1. A novel C40693T variant was significantly associated with an increased risk of infection, suggesting that there might be a role for APOBEC3G in susceptibility to HIV-1 infection that warrants further investigation.

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Year:  2006        PMID： 16988524     DOI： 10.1097/01.aids.0000247124.35129.e1

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  20 in total

Review 1.  Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all.

Authors:  Belete A Desimmie; Krista A Delviks-Frankenberrry; Ryan C Burdick; DongFei Qi; Taisuke Izumi; Vinay K Pathak
Journal:  J Mol Biol       Date:  2013-11-02       Impact factor: 5.469

2.  Accessory genes confer a high replication rate to virulent feline immunodeficiency virus.

Authors:  Ryan M Troyer; Jesse Thompson; John H Elder; Sue VandeWoude
Journal:  J Virol       Date:  2013-05-08       Impact factor: 5.103

Review 3.  Host genes associated with HIV/AIDS: advances in gene discovery.

Authors:  Ping An; Cheryl A Winkler
Journal:  Trends Genet       Date:  2010-02-10       Impact factor: 11.639

4.  Microarray analysis of HIV resistant female sex workers reveal a gene expression signature pattern reminiscent of a lowered immune activation state.

Authors:  Elijah M Songok; Ma Luo; Ben Liang; Paul Mclaren; Nadine Kaefer; Winnie Apidi; Genevieve Boucher; Joshua Kimani; Charles Wachihi; Rafick Sekaly; Keith Fowke; Blake T Ball; Francis A Plummer
Journal:  PLoS One       Date:  2012-01-26       Impact factor: 3.240

Review 5.  Determinants of protection among HIV‐exposed seronegative persons: an overview.

Authors:  Michael M Lederman; Galit Alter; Demetre C Daskalakis; Benigno Rodriguez; Scott F Sieg; Gareth Hardy; Michael Cho; Donald Anthony; Clifford Harding; Aaron Weinberg; Robert H Silverman; Daniel C Douek; Leonid Margolis; David B Goldstein; Mary Carrington; James J Goedert
Journal:  J Infect Dis       Date:  2010-11-01       Impact factor: 5.226

Review 6.  Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics.

Authors:  John S Albin; Reuben S Harris
Journal:  Expert Rev Mol Med       Date:  2010-01-22       Impact factor: 5.600

7.  Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets.

Authors:  Fransje A Koning; Edmund N C Newman; Eun-Young Kim; Kevin J Kunstman; Steven M Wolinsky; Michael H Malim
Journal:  J Virol       Date:  2009-07-08       Impact factor: 5.103

8.  Genetic variants in the host restriction factor APOBEC3G are associated with HIV-1-related disease progression and central nervous system impairment in children.

Authors:  Kumud K Singh; Yan Wang; Kathryn P Gray; Mona Farhad; Sean Brummel; Terence Fenton; Rodney Trout; Stephen A Spector
Journal:  J Acquir Immune Defic Syndr       Date:  2013-02-01       Impact factor: 3.731

9.  APOBEC3 versus Retroviruses, Immunity versus Invasion: Clash of the Titans.

Authors:  Ann M Sheehy; Julie Erthal
Journal:  Mol Biol Int       Date:  2012-06-06

Review 10.  Running loose or getting lost: how HIV-1 counters and capitalizes on APOBEC3-induced mutagenesis through its Vif protein.

Authors:  Carsten Münk; Björn-Erik O Jensen; Jörg Zielonka; Dieter Häussinger; Christel Kamp
Journal:  Viruses       Date:  2012-11-14       Impact factor: 5.048
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