Literature DB >> 16988485

From tau to toxicity: emerging roles of NMDA receptor in Alzheimer's disease.

Muhammad Omar Chohan1, Khalid Iqbal.   

Abstract

Glutamate toxicity through NMDA receptor channels has long been central to the understanding of acute neuronal injury. Recent studies implicate similar events in chronic neurodegenerative diseases. Here, we analyze some of the most intriguing evidence for NMDA receptor-mediated cellular dysfunction and propose a mechanism by which hyperactive NMDA receptors might lead to neurofibrillary degeneration in Alzheimer's disease.

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Year:  2006        PMID： 16988485     DOI： 10.3233/jad-2006-10112

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  19 in total

Review 1.  NMDA receptors and metaplasticity: mechanisms and possible roles in neuropsychiatric disorders.

Authors:  Charles F Zorumski; Yukitoshi Izumi
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Review 2.  Fission and fusion of the neuronal endoplasmic reticulum.

Authors:  K Kucharz; T Wieloch; H Toresson
Journal:  Transl Stroke Res       Date:  2013-08-24       Impact factor: 6.829

3.  Progress in the development of new drugs in Alzheimer's disease.

Authors:  Antoine Piau; F Nourhashémi; C Hein; C Caillaud; B Vellas
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4.  Altered microglial copper homeostasis in a mouse model of Alzheimer's disease.

Authors:  Zhiqiang Zheng; Carine White; Jaekwon Lee; Troy S Peterson; Ashley I Bush; Grace Y Sun; Gary A Weisman; Michael J Petris
Journal:  J Neurochem       Date:  2010-08-19       Impact factor: 5.372

5.  Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex.

Authors:  Dongman Chao; Xiaozhou He; Yilin Yang; Gianfranco Balboni; Severo Salvadori; Dong H Kim; Ying Xia
Journal:  Toxicol Sci       Date:  2012-04-02       Impact factor: 4.849

6.  Update on the use of memantine in Alzheimer's disease.

Authors:  Robert J van Marum
Journal:  Neuropsychiatr Dis Treat       Date:  2009-05-20       Impact factor: 2.570

7.  Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.

Authors:  Francesc X Soriano; Marc-Andre Martel; Sofia Papadia; Anne Vaslin; Paul Baxter; Colin Rickman; Joan Forder; Michael Tymianski; Rory Duncan; Michelle Aarts; Peter Clarke; David J A Wyllie; Giles E Hardingham
Journal:  J Neurosci       Date:  2008-10-15       Impact factor: 6.167

Review 8.  Ionotropic glutamate receptors & CNS disorders.

Authors:  Derek Bowie
Journal:  CNS Neurol Disord Drug Targets       Date:  2008-04       Impact factor: 4.388

9.  Progress update: Pharmacological treatment of Alzheimer's disease.

Authors:  David B Hogan
Journal:  Neuropsychiatr Dis Treat       Date:  2007       Impact factor: 2.570

10.  Critical appraisal of the long-term impact of memantine in treatment of moderate to severe Alzheimer's disease.

Authors:  Umamon Puangthong; Ging-Yuek Robin Hsiung
Journal:  Neuropsychiatr Dis Treat       Date:  2009-11-02       Impact factor: 2.570
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