Literature DB >> 16988007

Association of selective HLA class II susceptibility-conferring and protective haplotypes with type 2 diabetes in patients from Bahrain and Lebanon.

Wassim Y Almawi1, Saria F Wakim-Ghorayeb, Mona R Arekat, Pierre Najm, Sose H Keleshian, Nasreen Al-Sayed, Bruno Blanchon, Hanady R Samaha, Noha Irani-Hakime.   

Abstract

The association of HLA class II with type 2 diabetes (T2DM) was investigated in Bahraini and Lebanese subjects. DRB1*070101 (Lebanese and Bahraini) and DQB1*0201 (Lebanese) were susceptibility-conferring alleles, and unique susceptibility-conferring/protective haplotypes were found in both patient groups. Regression analysis confirmed that DRB1*070101-DQB1*0201 (Bahraini) and DRB1*110101-DQB1*0201 (Lebanese) were susceptibility-conferring haplotypes.

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Year:  2006        PMID： 16988007      PMCID： PMC1656545          DOI： 10.1128/CVI.00206-06

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


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