PURPOSE: Amniotic membrane has been successfully used for treatment of various ocular surface disorders, but there have been no published reports untill now regarding its use in the treatment of contracted socket. The aim of this study was to determine the role of amniotic membrane and to compare the results with mucous membrane grafting in anophthalmic contracted socket. METHODS: A prospective study of 20 eyes with mild to moderate anophthalmic contracted socket was carried out. Two groups, each with 10 eyes, were formed randomly. Group A underwent amniotic membrane transplantation, and Group B mucous membrane grafting. Prosthesis was fitted 6-8 weeks post operatively. The volume and fornices' length was compared preoperatively and at 3, 6 and 12 months postoperatively. RESULTS: Apart from measurements, patient satisfaction was an important criteria in defining the success of the procedure. At the end of 12 months, the relative increase between the 2 groups in the fornix and volume measurements were statistically significant (SF-0.001,IF-0.001,V-0.001) with better patient comfort in group A. There was no statistical significance regarding the rate of complications between both the groups (p = 0.29). CONCLUSION: Amniotic membrane emerges as a viable alternative to established mucous membrane grafting as it causes less patient morbidity, faster recovery and better fitting of prosthesis. No contracture is observed with amniotic membrane as against mucous membrane. It is cheap and easily available and has no significant complications associated with it.
RCT Entities:
PURPOSE: Amniotic membrane has been successfully used for treatment of various ocular surface disorders, but there have been no published reports untill now regarding its use in the treatment of contracted socket. The aim of this study was to determine the role of amniotic membrane and to compare the results with mucous membrane grafting in anophthalmic contracted socket. METHODS: A prospective study of 20 eyes with mild to moderate anophthalmic contracted socket was carried out. Two groups, each with 10 eyes, were formed randomly. Group A underwent amniotic membrane transplantation, and Group B mucous membrane grafting. Prosthesis was fitted 6-8 weeks post operatively. The volume and fornices' length was compared preoperatively and at 3, 6 and 12 months postoperatively. RESULTS: Apart from measurements, patient satisfaction was an important criteria in defining the success of the procedure. At the end of 12 months, the relative increase between the 2 groups in the fornix and volume measurements were statistically significant (SF-0.001,IF-0.001,V-0.001) with better patient comfort in group A. There was no statistical significance regarding the rate of complications between both the groups (p = 0.29). CONCLUSION: Amniotic membrane emerges as a viable alternative to established mucous membrane grafting as it causes less patient morbidity, faster recovery and better fitting of prosthesis. No contracture is observed with amniotic membrane as against mucous membrane. It is cheap and easily available and has no significant complications associated with it.