BACKGROUND: Classic KS (CKS) mainly affects elderly people, has an irregular course, and is relatively benign for years. However, sometimes the disease may progress rapidly and spread to internal organs, thus necessitating systemic chemotherapy. We therefore decided to carry out a prospective trial using vinblastine and bleomycin, which are active, easy to administer and control, and low cost. METHODS: We treated 29 patients affected by CKS with vinblastine i.v., up to 10 mg in combination with bleomycin i.m., 15 IU every 3 weeks. We administered a median of seven cycles of therapy. RESULTS: All the 29 enrolled patients were evaluated: 21% reached a complete response and 76% had an intermediate response. Toxicity was limited. The maximal response was attained in a median of 5 months, with a mean duration of 4 months. CONCLUSION: The combination of vinblastine and bleomycin achieved a high rate of objective responses in a subgroup of elderly and symptomatic patients, without considerable toxicity. We recommend the combination as first line chemotherapy for advanced CKS.
BACKGROUND:Classic KS (CKS) mainly affects elderly people, has an irregular course, and is relatively benign for years. However, sometimes the disease may progress rapidly and spread to internal organs, thus necessitating systemic chemotherapy. We therefore decided to carry out a prospective trial using vinblastine and bleomycin, which are active, easy to administer and control, and low cost. METHODS: We treated 29 patients affected by CKS with vinblastine i.v., up to 10 mg in combination with bleomycin i.m., 15 IU every 3 weeks. We administered a median of seven cycles of therapy. RESULTS: All the 29 enrolled patients were evaluated: 21% reached a complete response and 76% had an intermediate response. Toxicity was limited. The maximal response was attained in a median of 5 months, with a mean duration of 4 months. CONCLUSION: The combination of vinblastine and bleomycin achieved a high rate of objective responses in a subgroup of elderly and symptomatic patients, without considerable toxicity. We recommend the combination as first line chemotherapy for advanced CKS.
Authors: Pasquale Rescigno; Rossella Di Trolio; Carlo Buonerba; Gaia De Fata; Piera Federico; Davide Bosso; Antonella Virtuoso; Michela Izzo; Tania Policastro; Luca Vaccaro; Gianfranco Cimmino; Francesco Perri; Elide Matano; Mario Delfino; Sabino De Placido; Giovannella Palmieri; Giuseppe Di Lorenzo Journal: World J Clin Oncol Date: 2013-05-10
Authors: Noemy Starita; Gianluca Di Monta; Andrea Cerasuolo; Ugo Marone; Anna Maria Anniciello; Gerardo Botti; Luigi Buonaguro; Franco M Buonaguro; Maria Lina Tornesello Journal: Infect Agent Cancer Date: 2017-06-19 Impact factor: 2.965