| Literature DB >> 16986975 |
Myra Beaudoin Bertrand1, John P Wolfe.
Abstract
A new tandem Wittig Rearrangement/aldol reaction of O-benzyl or O-allyl glycolate esters is described. This reaction generates two carbon-carbon bonds and two contiguous stereocenters in a single step from simple starting materials. The [1,2]-Wittig rearrangement proceeds under very mild reaction conditions that do not require the use of a strong base, and the 1,2-diol products are obtained in good yield with excellent diastereoselectivity (>20:1).Entities:
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Year: 2006 PMID： 16986975 DOI： 10.1021/ol062016l
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005