Literature DB >> 16986957

Real-time monitoring of microwave-promoted Suzuki coupling reactions using in situ Raman spectroscopy.

Nicholas E Leadbeater1, Rebecca J Smith.   

Abstract

The progress of microwave-promoted Suzuki reactions has been monitored using an in situ Raman spectroscopy apparatus assembled from commercially available components. It was possible to see if any reaction occurred and, if so, when it reached completion. In addition, the monitoring technique has given us an insight into the reaction, confirming that, when run in aqueous media, the coupling is in competition with the rapid deboronation of the boronic acid.

Entities:  

Year:  2006        PMID: 16986957     DOI: 10.1021/ol061803f

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  3 in total

Review 1.  Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

2.  Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example.

Authors:  Trevor A Hamlin; Nicholas E Leadbeater
Journal:  J Vis Exp       Date:  2015-11-18       Impact factor: 1.355

3.  Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions.

Authors:  Trevor A Hamlin; Nicholas E Leadbeater
Journal:  Beilstein J Org Chem       Date:  2013-09-11       Impact factor: 2.883

  3 in total

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