| Literature DB >> 16986952 |
Frederic Menard1, Timothy M Chapman, Chris Dockendorff, Mark Lautens.
Abstract
An enantio-, regio-, and diastereoselective rhodium(I)-catalyzed desymmetrization of a meso-cyclic allylic dicarbonate with organoboronic acid nucleophiles is described. The rhodium(I) catalyst formed in situ from [Rh(cod)OH]2 and Xyl-P-PHOS allowed the S(N)2' allylic substitution product to be obtained with a range of arylboronic acids in enantiomeric excesses of up to 92% with regioselectivities of up to >20:1.Entities:
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Year: 2006 PMID： 16986952 DOI： 10.1021/ol061777l
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005